DACH1

DACH1

A gene on chromosome 13q22 that encodes a chromatin-associated protein, which associates with other DNA-binding transcription factors to regulate gene expression and cell fate during development. DACH1 expression is lost in some metastatic cancers, and is a marker of poor prognosis.
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[149], a combination of small molecules A-8301 (inhibitor of TGF-beta), thiazovivin (ROCK inhibitor), purmorphamine (SHH agonist), and valproic acid (VPA: inhibitor of histone deacetylase (HDAC)) was chosen, resulting in the production of NSC positive for Sox2, Pax6, PLZF, Dach1, Fam70a, Nr2f1, and Zic1 from murine fibroblasts, which were then differentiated into functional neurons, astrocytes, and oligodendrocytes positive for Tuj1, GFAP, and Olig2, respectively.
Yuan et al., "DACH1 is a novel predictive and prognostic biomarker in hepatocellular carcinoma as a negative regulator of Wnt/[beta]-catenin signaling," Oncotarget, vol.
(Yorkshire) RAB22A (2012) 11 Composite population DACH1 Schneider et al.