DRD2

(redirected from D2R)
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DRD2

A gene on chromosome 11q23 that encodes G protein-coupled dopamine receptor D2, which inhibits adenylyl cyclase.

Molecular pathology
Defects in DRD2 are associated with myoclonic dystonia.
References in periodicals archive ?
These changes are associated with decreased D2R mRNA and protein.
Ethanol affects prolactin levels not only through its impact on D2R but also through changes in the production and secretion of growth factors in the pituitary that help control lactotropic cell proliferation.
Although the alstonine mechanism of action has not been fully clarified, behavioral and neurochemical data suggest it is not a D2R antagonist (Costa-Campos et al.
If proven, the apparent lack of D2R blockade by alstonine would represent an innovative pharmacodynamic basis for antipsychotic properties.
The data obtained in this study corroborate our previous hypothesis that alstonine does not bind to D2R because the QAR data clearly demonstrate that alstonine does not bind to D2R.
Neurochemical studies of the brains of patients with liver disease have confirmed for the most part the results from neuroimaging studies: a significant decrease in D2R levels in the basal ganglia and no observed decrease in dopamine levels (Table 1).
Liver disease Loss of D2R in GP 1995 Mousseau et al.
1] x ARK8518 from the above source were evaluated, D8R was again crossed as the female parent to D2R in 1997 and individual plant lineages subsequently maintained.
1] plants of CMS-D8 x D2R were all fertile and had normal-sized flowers and pollen shed, indicating that restoration of CMS-D8 by D2R was complete.
Tenders are invited for Restoration work of Minor M3R / D2R of B.
D2R acts by ligand-dependent signalling through two major systems: the G-proteins, and the Arrestin proteins (Arr-s).