serine

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Related to D-serine: L-serine

serine

 [sēr´ēn]
a naturally occurring, nonessential amino acid, used as a dietary supplement, in biological studies and tests, and in culture media.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

ser·ine (S, Ser),

(ser'ēn),
2-Amino-3-hydroxypropanoic acid; the l-isomer is one of the amino acids occurring in proteins.
Farlex Partner Medical Dictionary © Farlex 2012

serine

(sĕr′ēn′)
n.
An amino acid, C3H7NO3, that is a common constituent of many proteins.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

SERPING1

A gene on chromosome 11q12-q13.1 that encodes a highly glycosylated plasma protein which regulates the complement cascade by inhibiting activated C1r and C1s, thereby preventing complement activation.

Molecular pathology
C1-INH/SERPING1 deficiency is associated with hereditary angioneurotic oedema (HANE).
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

ser·ine

(S) (sĕr'ēn)
One of the amino acids occurring in proteins.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

serine

A non-essential amino acid found as a component of most proteins. It is a precursor of choline, glucine, cysteine and pyruvate. Serine is present in most diets but most of the body serine is synthesized.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
Serineclick for a larger image
Fig. 282 Serine . Molecular structure.

serine (S, Ser)

one of 20 AMINO ACIDS common in proteins. It has a polar ‘R’ group structure and is soluble in water. See Fig. 282 . The ISOELECTRIC POINT of serine is 5.7.
Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005

ser·ine

(sĕr'ēn)
One of the amino acids occurring in proteins.
Medical Dictionary for the Dental Professions © Farlex 2012
References in periodicals archive ?
Furthermore, in contrast to non-deuterated D-serine, which has been reported to display highly variable pharmacokinetic behavior in humans, CTP-692 was found to have low inter-individual pharmacokinetic variability.
D-serine has emerged as a novel regulatory factor giving a new twist to glutamatergic transmission and how aging can affect it.
Some studies reported that glycine primarily targeted the extrasynaptic NMDARs while D-serine regulates the activity of synaptic NMDARs [84].
The CTP-692 clinical program is supported by results from Concert's preclinical studies which have shown the potential of CTP-692 to improve upon the safety profile of D-serine.
In addition to glycine, D-serine also acts as an agonist at GluN3A subunits, again with a higher affinity than GluN1.
Citrome went on to explain that for an NMDA receptor to be activated, both glutamate and glycine are required, adding that "d-serine also has high affinity for the glycine site on NMDA receptors."
The NMDAR contains modulatory sites that may be appropriate targets for drug development, including one that binds the amino acids glycine and D-serine and a redox site that is sensitive to brain glutathione levels.
In order to continue to delineate the role of NMDA receptors in the effector systems of Hydra vulgaris, we investigated the effects of NMDA, together with D-serine, the specific glycine agonist at the NMDA receptor (Kleck-ner and Dingledine, 1988; Mothet et al., 2000), on the electrical activity of hydra's epitheliomuscular systems.
Contributors treat toxicity issues relating to specific classes of drugs (e.g., antipsychotics, topical corticosteroids, COX-2 inhibitors); and the perplexing question of why the amino acid D-Serine is nephrotoxic in some experimental animals but not others.
D-Serine, generally regarded as an atypical enantiomer, is known to be a coagonist for the glycine binding site (NR1/NR2) of the N-methyl-D-aspartate (NMDA) [3] receptors and has a brain-selective and NMDA receptor R2B subunit-related distribution in the mammalian brain (1-4).