penicillamine

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Related to D-penicillamine: Cuprimine

penicillamine

 [pen″ĭ-sil´ah-mēn]
a degradation product of penicillin that chelates certain heavy metals; used orally to reduce the blood copper level in Wilson's disease and to promote excretion of cystine in patients with cystinuria or recurrent cystine renal calculus formation, by helping to solubilize cystine. It is also used as a disease-modifying antirheumatic drug in treatment of refractory rheumatoid arthritis.

pen·i·cil·la·mine

(pen'i-sil'ă-mēn),
A degradation product of penicillin; a chelating agent used in the treatment of lead poisoning, hepatolenticular degeneration, and cystinuria, and in the removal of excess copper in Wilson disease.
Synonym(s): β, β-dimethylcysteine

penicillamine

(pĕn′ĭ-sĭl′ə-mēn′)
n.
A chelating agent, C5H11NO2S, that is a degradation product of penicillin and is used in the treatment of Wilson disease, refractory rheumatoid arthritis, and excess urinary excretion of cystine.

penicillamine

Metabolic disease A drug that removes copper, lead, mercury, and other metals from the body, which inhibit angiogenesis in brain tumors

pen·i·cil·la·mine

(pen'i-sil'ă-mēn)
A degradation product of penicillin; a chelating agent used to treat lead poisoning, hepatolenticular degeneration, and cystinuria.
Synonym(s): β, β-dimethylcysteine.

penicillamine

A drug used to treat severe RHEUMATOID ARTHRITIS not responding to nonsteroidal anti-inflammatory drugs (NSAIDs).

Penicillamine is a CHELATING AGENT and is also used to treat poisoning with metallic salts or disorders such as WILSON'S DISEASE. The drug is on the WHO official list. Brand names are Distamine and Pendramine.

Penicillamine (Cuprimine, Depen)

A drug used to treat medical problems (such as excess copper in the body and rheumatoid arthritis) and to prevent kidney stones. It is also sometimes prescribed to remove excess lead from the body.
Mentioned in: Lead Poisoning

pen·i·cil·la·mine

(pen'i-sil'ă-mēn)
Degradation product of penicillin used to treat lead poisoning, hepatolenticular degeneration, and cystinuria.
References in periodicals archive ?
The other group of six test rats was given distilled water for one week followed by a six week period of 25-35 mg/kg-b-wt/day of oral D-penicillamine treatment.
In conclusion the present study showed that lead induced hematological changes were reversible after a period of recovery and D-penicillamine treatment did not effect in the improvement of impaired parameters affected by lead intoxication.
"D-penicillamine: Its actions on lead transport in bone organ culture." Pediatr Res, 1980; 14:330-335.
"Experience with d-penicillamine in treating lead poisoning." Vet Hum Toxicol, 1982; 24:18-20.
DMSA, DMPS, EDTA, and D-penicillamine have been used for provocative tests to quantify body burden of toxic minerals.
Method: A short course of D-penicillamine (Cupramine; De-Pen) or N-acetyl-D-penicillamine is prescribed by your health professional.
Program: Take 500 mg (2 capsules of 250 mg each) D-penicillamine or N-acetyl-D-penicillamine with each meal and before bed for 3 days.
One group will be treated with D-penicillamine, the traditional therapy for scleroderma, and the other will be treated with photopheresis."
Only few good results have been reported with oral dimethyl sulphoxide (DMSO) D-penicillamine etretinate and acitretin.
D-penicillamine tests for essential and toxic minerals: measurement of buffering minerals using such standardized and validated protocols such as the d-penicillamine provocation tests for both essential and for toxic minerals (19) (Tables 1 and 2) Table 1: Mineral value ranges for nutritional and toxic minerals in second-day 24[degrees] urine after d-penicillamine provocation, 7.5 mg./kgm; q.i.d.
According to some reports isolated cases of cutis laxa have been reported in patients undergoing D-penicillamine therapy (copper chelator) such as those with Wilson's disease due to the elastolytic effect of D-penicillamine.8