glucuronic acid

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Related to D-glucuronic acid: glucuronic acid pathway

glucuronic acid

 [gloo″ku-ron´ik]
a uronic acid formed by oxidation of C-6 of glucose to a carboxy group; it occurs in proteoglycans (mucopolysaccharides), and is important in the conjugation of xenobiotics; it is conjugated to many poisons and drugs by the liver, forming glucuronides, which markedly decreases their toxicity and enhances their excretion by the liver, intestine, and kidney.

glu·cu·ron·ic ac·id

(glū'kū-ron'ik as'id),
The uronic acid of glucose in which C-6 is oxidized to a carboxyl group; the d-isomer detoxicates or inactivates various substances (for example, benzoic acid, phenol, camphor, and the female sex hormones) undergoing conjugation with such substances in the liver, the glucuronides so formed being excreted in the urine.

glu·cu·ron·ic ac·id

(glū'kyūr-on'ik as'id)
The uronic acid of glucose in which C-6 is oxidized to a carboxyl group; the d-isomer detoxicates or inactivates various substances (e.g., benzoic acid, phenol, camphor, and the female sex hormones), the glucuronides so formed being excreted in the urine.

glucuronic acid

A substance formed from glucose that combines with many body waste products to form glycosides that are excreted in the urine.
References in periodicals archive ?
Abbreviations BSTFA + 1% TMCS: N,O-Bis(trimethylsilyl)trifluoroacetamide with 1% trimethylchlorosilane DCM: Dichloromethane DGA: D-Glucaric acid DGuA: D-Glucuronic acid GL: Glucuronolactone DMF: Dimethilformamide GC: Gas chromatography HPLC: High-performance liquid chromatography LOD: Limit of detection LOQ: Limit of quantification MS: Mass spectroscopy RSD: Relative standard deviance TMS: Trimethylsilyl.
Abbreviations: GAG: glycosaminoglycan; HA: hyaluronan; Ch: chondroitin; ChS: chondroitin sulfate; Ch4S: chondroitin 4-sulfate; Ch6S: chondroitin 6-sulfate; ChSE: chondroitin sulfate E; DS: dermatan sulfate; Xyl: d-xylose; Gal: d-galactose; GlcUA: d-glucuronic acid; IdoUA: L-iduronic acid; GlcNAc: N-acetyld-glucosamine; GalNAc: N-acetyl-d-galactosamine; GlcUA GlcNAc: -4GlcUA[beta]1-3GlcNAc[beta]1-; GlcUA-GalNAc:-4GlcUA[beta]1 3GalNAc[beta]1-;GlcUA-GalNAc4S: -4GlcUA[beta]1-3GalNAc(-4-sul fate)O1-; GlcUA-GalNAc6S: -4GlcUA[beta]1-3GalNAc(-6-sulfate)[beta]1-; GlcUA-GalNAc4S,6S: -4GlcUA[beta]1-3GalNAc(-4,6-disulfates)[beta]1-; IdoUA-GalNAc4S: -4IdoUAa1-3GalNAc(-4-sulfate)[beta]1-; GlcUAGal-Gal-Xyl-Ser: GlcUA[beta]1-3Gal[beta]1-3Gal[beta]1-4Xyl[beta]1-Ser.
D-Glucuronic acid (GlcA) sodium salt monohydrate and N-acetylgalactosamine (GalNAc) were purchased from Sigma Chemical Co.
Hyaluronic acid (HA) is a high molecular weight non-sulfated glycosaminoglycan composed of repeating disaccharide unit of D-glucuronic acid (Glc UA) and A-acettyl-D-glucosamine (NAG).