d-dimer


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Related to d-dimer: d-dimer test

dimer

 
1. a compound formed by combination of two identical simpler molecules.
2. a capsomer having two structural subunits.
D-dimer a fragment of fibrin that is formed as a result of fibrin degradation. A positive test for its presence in the blood is suggestive of conditions such as thrombotic disease, sickle cell crisis, malignancy, disseminated intravascular coagulation, or recent surgery.

d-dimer

a dimer byproduct resulting from fibrinolysis; produced by cross linkage of d-domain fibrin monomers by activated factor XIII, fibrin stabilizing factor; present in low levels in normal animals, but found at particularly high levels in association with thrombotic and hemostatic disorders; assayed as an adjunctive diagnostic tool in conditions such as malignant neoplasia, infectious disease, immune-mediated hemolytic anemia, immune-mediated thrombocytopenia, hyperadrenocorticism, pulmonary thromboembolism, and disseminated intravascular coagulation or DIC. d-dimer production requires both plasmin and thrombin activation. Note that generation of fibrin/fibrinogen degradation products (FDPs) requires only plasmin action on fibrin or fibrinogen. d-dimers clear through urinary excretion, so assay may show falsely increased levels during renal dysfunction. Laboratory ELISA measurement can identify fibrinolysis.

d-dimer

Hematology A fibrin split product that can be used in a sensitive assay of plasmin activity, which is often ↑ in systemic consumptive coagulopathy, ie DIC. See Disseminated intravascular coagulation, Fibrin split products.

d-dimer

A covalently cross-linked degradation product released from the cross-linked fibrin polymer during plasmin-mediated fibrinolysis. Laboratory measurements of this product are made using latex bead assay, or enzyme-linked immunosorbent assay can be used to identify the presence of fibrinolysis; helpful in diagnosis of deep vein thrombosis.

d-dimer

(dī'mer)
A covalently cross-linked degradation product released from the cross-linked fibrin polymer during plasmin-mediated fibrinolysis. Laboratory measurements of this product are made using latex bead assay, or enzyme-linked immunosorbent assay, and can be used to identify the presence of fibrinolysis; helpful in diagnosis of deep vein thrombosis.
References in periodicals archive ?
"This decreasing specificity can be explained by the physiological rise in the D-dimer level that commonly occurs during pregnancy," said Dr.
The expression of D-dimer, miR203 and CD147 was measured for all the patients.
Then, the abdomen was closed, and blood was obtained from an ear vein to determine the IL-2, IL-6, PCT, and D-dimer levels.
Changes in plasma levels of thrombomodulin and D-dimer in children with different types of Mycoplasma pneumoniae pneumonia.
"Future research should focus on increasing the yield of noninvasive testing, such as by developing a specific clinical decision rule for suspected PE during pregnancy or using pregnancy-adapted D-dimer cut-off values," the authors write.
Atherosclerosis underlying cardiovascular mortality is the leading cause of death in developed countries.3 D-dimer is a fibrin degradation product (or FDP), a small protein fragment present in the blood after a blood clot is degraded by fibrinolysis.
A positive NLR was considered 3.4 or higher, a positive PLR was a ratio of 230 or more, and a positive D-dimer level was 500 ng/mL or greater.
D-dimer testing in the diagnosis of transfemoral pseudoaneurysm after percutaneous transluminal procedures.
Recent studies revealed that indicators of the inflammatory reaction white blood cells, PLTc and D-dimer level, are closely associated with clinical outcomes in aortic events (24-30).
D-dimer levels were measured at the time of commencement of treatment.