cytotoxicity

(redirected from Cytoxicity)
Also found in: Dictionary, Thesaurus.

cytotoxicity

 [si″to-tok-sis´ĭ-te]
1. the degree to which an agent has specific destructive action on certain cells.
2. the possession of such destructive action, particularly in reference to lysis of cells by immune phenomena and to antineoplastic agents that selectively kill dividing cells. adj., adj cytotox´ic.
antibody-dependent cell-mediated cytotoxicity (ADCC) (antibody-dependent cellular cytotoxicity) lysis of target cells coated with antibody by effector cells with cytolytic activity and specific immunoglobulin receptors called Fc receptors, including K cells, macrophages, and granulocytes. Lysis of the target cell is extracellular, requires direct cell-to-cell contact, and does not involve complement.
cell-mediated cytotoxicity destruction of a target cell by specific lymphocytes, such as cytotoxic T lymphocytes or NK cells; it may be antibody-dependent (see antibody-dependent cell-mediated c.) or independent, as in certain cell-mediated hypersensitivity reactions.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

cy·to·tox·ic·i·ty

(sī'tō-tok-sis'i-tē),
The quality or state of being cytotoxic.
Farlex Partner Medical Dictionary © Farlex 2012

cy·to·tox·ic·i·ty

(sī'tō-tok-sis'i-tē)
The quality or state of being cytotoxic.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

cytotoxicity

The property of being able to cause damage to, or death of, cells.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

cy·to·tox·ic·i·ty

(sī'tō-tok-sis'i-tē)
The qual-ity or state of being cytotoxic.
Medical Dictionary for the Dental Professions © Farlex 2012
References in periodicals archive ?
Exposure of these two malignant cell lines to RF alone also produced some cytoxicity, although significantly less cytotoxicity than the GNP RF combination.
The product is supplied with a 76# white polycoated kraft release liner, and has passed skin irritation, cytoxicity, and sensitization product safety testing.
The product is supplied with a 76# white polycoated kraft release liner and has passed skin irritation, cytoxicity, and sensitization product safety testing.
The product is supplied with a 76 pound white polycoated kraft release liner and has passed skin irritation, cytoxicity and sensitization product safety testing.
Another study displayed the anticancer properties of dandelion roots because of their cytoxicity to human hepatoma cancer cells.
Endpoint type M: Example of [M.sup.*]: Example (examples) toxicologically of critical effect equivalent effect size(s) metric Continuous Percent change 5%, 10% (percent (hematocrit, serum relative to control change) enzyme, BW, organ/BW ratio) Deterministic Severity category "Minimal" (severity quantal (hepatic category) lesions, cytoxicity) Stochastic quantal Extra risk for 1%, 5%, 10% (extra (hepatic tumors, individual risk) fetal resorptions, probability of eye malformations) occurrence Endpoint type Benchmark dose (examples) approach Continuous Continuous models (hematocrit, serum with BMR = [M.sup.*] enzyme, BW, organ/BW = 5%, 10%.
Xanthoangelol and 4-hydroxyderricin showed 32 [+ or -] 1 and 33 [+ or -] 1% cytoxicity at 50 [micro]M, and 54 [+ or -] 2 and 45 [+ or -] 2% cytotoxicity at 100 [micro]M, against LM8 cells, respectively.
Yee, "Combined targeting of histone deacetylases and hedgehog signaling enhances cytoxicity in pancreatic cancer," Cancer Biology & Therapy, vol.
Prevention of cytoxicity and inhibition of intercellular communication antioxidant catechins isolated from Chinese green tea.
Bacterial cytotoxicity was evaluated by lactate dehydrogenase measurement with Cyto-Tox 96 Cytoxicity Kit (Promega, Madison, WI, USA) according to the manufacturer's instructions.