cytotoxicity

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cytotoxicity

 [si″to-tok-sis´ĭ-te]
1. the degree to which an agent has specific destructive action on certain cells.
2. the possession of such destructive action, particularly in reference to lysis of cells by immune phenomena and to antineoplastic agents that selectively kill dividing cells. adj., adj cytotox´ic.
antibody-dependent cell-mediated cytotoxicity (ADCC) (antibody-dependent cellular cytotoxicity) lysis of target cells coated with antibody by effector cells with cytolytic activity and specific immunoglobulin receptors called Fc receptors, including K cells, macrophages, and granulocytes. Lysis of the target cell is extracellular, requires direct cell-to-cell contact, and does not involve complement.
cell-mediated cytotoxicity destruction of a target cell by specific lymphocytes, such as cytotoxic T lymphocytes or NK cells; it may be antibody-dependent (see antibody-dependent cell-mediated c.) or independent, as in certain cell-mediated hypersensitivity reactions.

cy·to·tox·ic·i·ty

(sī'tō-tok-sis'i-tē),
The quality or state of being cytotoxic.

cy·to·tox·ic·i·ty

(sī'tō-tok-sis'i-tē)
The quality or state of being cytotoxic.

cytotoxicity

The property of being able to cause damage to, or death of, cells.

cy·to·tox·ic·i·ty

(sī'tō-tok-sis'i-tē)
The qual-ity or state of being cytotoxic.
References in periodicals archive ?
Exposure of these two malignant cell lines to RF alone also produced some cytoxicity, although significantly less cytotoxicity than the GNP RF combination.
The product is supplied with a 76# white polycoated kraft release liner, and has passed skin irritation, cytoxicity, and sensitization product safety testing.
The product is supplied with a 76# white polycoated kraft release liner and has passed skin irritation, cytoxicity, and sensitization product safety testing.
The product is supplied with a 76 pound white polycoated kraft release liner and has passed skin irritation, cytoxicity and sensitization product safety testing.
Another study displayed the anticancer properties of dandelion roots because of their cytoxicity to human hepatoma cancer cells.
Endpoint type M: Example of [M.sup.*]: Example (examples) toxicologically of critical effect equivalent effect size(s) metric Continuous Percent change 5%, 10% (percent (hematocrit, serum relative to control change) enzyme, BW, organ/BW ratio) Deterministic Severity category "Minimal" (severity quantal (hepatic category) lesions, cytoxicity) Stochastic quantal Extra risk for 1%, 5%, 10% (extra (hepatic tumors, individual risk) fetal resorptions, probability of eye malformations) occurrence Endpoint type Benchmark dose (examples) approach Continuous Continuous models (hematocrit, serum with BMR = [M.sup.*] enzyme, BW, organ/BW = 5%, 10%.
Xanthoangelol and 4-hydroxyderricin showed 32 [+ or -] 1 and 33 [+ or -] 1% cytoxicity at 50 [micro]M, and 54 [+ or -] 2 and 45 [+ or -] 2% cytotoxicity at 100 [micro]M, against LM8 cells, respectively.
Yee, "Combined targeting of histone deacetylases and hedgehog signaling enhances cytoxicity in pancreatic cancer," Cancer Biology & Therapy, vol.
Prevention of cytoxicity and inhibition of intercellular communication antioxidant catechins isolated from Chinese green tea.
Bacterial cytotoxicity was evaluated by lactate dehydrogenase measurement with Cyto-Tox 96 Cytoxicity Kit (Promega, Madison, WI, USA) according to the manufacturer's instructions.