cytotoxic T cell

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cytotoxic T cell

The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

cytotoxic T cell

A CD8+ T lymphocyte that can destroy microorganisms directly through the release of perforin and proteolytic enzymes. These cells are particularly important in the defense against viruses, rejection of allografts, and, possibly, new malignant cells. Synonym: CD8 cell; cytotoxic cel; killer T cell
See also: cell
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
The clinical presentation of FHL includes primarily fever, hepatomegaly, and cytopenia, which are the results of functional degradation in cytotoxic T-lymphocytes and natural killer (NK)-cells, activation of macrophages and T-lymphocytes, excessive production of proinflammatory cytokines, and hemophagocytosis (1-3).
It's not the levels of cytotoxic T-lymphocytes in human volunteers, nor levels of neutralizing antibodies; it's not all these fancy immunologic measurements.
Cytotoxic T-lymphocytes (CTL) specific to cytomegalovirus (CMV) antigens decline significantly during the first 6 months following liver transplantation, a finding that may explain the increased vulnerability to CMV observed in this patient population.
For this reason, many researchers are trying to create vaccines that stimulate cytotoxic T-lymphocytes (CTLs), immune-system cells that kill virus-infected cells in the body.
The results also demonstrate the pharmacodynamic effect of modulating the appropriate genes associated with the interferon gamma pathway and cytotoxic T-lymphocytes, which are 2 of 3 biomarker components of the Alopecia Areata Disease Activity Index, or ALADIN, score.
Mucosal infection by intracellular pathogens results in the induction of cell-mediated immunity, as manifested by CD4-positive ([CD4.sup.+]) T helper-type 1 cells, as well as [CD8.sup.8] cytotoxic T-lymphocytes. These responses are normally accompanied by the synthesis of secretory immunoglobulin A (S-IgA) antibodies, which provide an important first line of defense against invasion of deeper tissues by these pathogens.
Recently, her research group studied how TCDD affects a mouse's production of cytotoxic T-lymphocytes, which destroy cells infected with viral invaders.