cytotoxic T cell

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cytotoxic T cell

cytotoxic T cell

See CD8 cell.

cytotoxic T cell

A CD8+ T lymphocyte that can destroy microorganisms directly through the release of perforin and proteolytic enzymes. These cells are particularly important in the defense against viruses, rejection of allografts, and, possibly, new malignant cells. Synonym: CD8 cell; cytotoxic cel; killer T cell
See also: cell
References in periodicals archive ?
When the immune system is triggered by an infectious agent histiocytes (macrophages and dendritic cells), NK-cells, and cytotoxic T-lymphocytes (CTLs) are activated, mutually stimulating each other via receptor interaction, as well as secretion of a variety of inflammatory cytokines and chemokines.
According to pre-clinical results, these PME-CD40L dendritic cells drive stronger effector memory in cytotoxic T-lymphocytes (CTLs) in comparison to mature dendritic cells generated with cytokines alone, making them better able to recognize cancer antigens.
Immunological assays revealed the generation of cytotoxic T-lymphocytes (CTLs) against MUC1 positive tumour cell lines in 5 of 12 patients.
The telomerase-specific cytotoxic T-lymphocytes (CTLs) isolated from the peripheral blood of vaccinated study subjects killed telomerase targets in vitro.
The authors had previously found that telomere loss in cytotoxic T-lymphocytes (CTLs), the cells responsible for killing HIV-infected cells, was accelerated in AIDS patients, and contributed to the loss of anti-HIV activity that occurs during disease progression.
Those publications, as well as subsequent research, demonstrated that messenger RNA encoding the catalytic reverse transcriptase protein component of human telomerase (hTERT mRNA), when introduced into dendritic cells, can stimulate the immune system to produce cytotoxic T-lymphocytes (CTLs, or killer T-cells) capable of recognizing and destroying telomerase-positive cancer cells.
Telomerase was introduced into human dendritic cells by gene transfer enabling the dendritic cells to generate telomerase specific cytotoxic T-lymphocytes (CTLs) that killed all three tumor cell lines.