cytotoxic T cell

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cytotoxic T cell

cytotoxic T cell

See CD8 cell.

cytotoxic T cell

A CD8+ T lymphocyte that can destroy microorganisms directly through the release of perforin and proteolytic enzymes. These cells are particularly important in the defense against viruses, rejection of allografts, and, possibly, new malignant cells. Synonym: CD8 cell; cytotoxic cel; killer T cell
See also: cell
References in periodicals archive ?
Studies have shown that T-cell vaccination resulted in the in vivo induction of CD8+ cytotoxic T-cells and CD4+CD25+FoxP3 Tregs specific for T-cell vaccine.
Studies of T-cell vaccine have indicated that T-cell vaccination with peripheral blood-derived autologous myelin-peptide selected T-cells in MS patients resulted in the in vivo induction of CD8+ cytotoxic T-cells and CD4+CD25+FoxP3 Tregs specific for T-cell vaccine.
Studies of T-cell vaccine have indicated that T-cell vaccination with peripheral blood-derived autologous myelin-peptide selected T-cells in multiple sclerosis patients resulted in the in vivo induction of CD8+ cytotoxic T-cells and CD4+CD25+FoxP3 Tregs specific for T-cell vaccine.
In vitro studies have demonstrated that autologous dendritic cells transfected with hTERT mRNA stimulate hTERT-specific cytotoxic T-cells (CTL) from the peripheral blood of patients with cancer.
The study conducted by Chen and coworkers, indicated that T-cell vaccination with autologous selected synovial T-cells in rheumatoid arthritis patients resulted in the induction of CD4+ Tregs and CD8+ cytotoxic T-cells specific for T-cell vaccine.
This novel cytokine has potent biological activity in regulating key classes of immune cells, including cytotoxic T-cells and NK cells, which are thought to play key roles in eliminating malignant and infected cells from the body.
As HIV disease progresses, certain immune cells called CD8 cytotoxic T-cells undergo accelerated replicative senescence (cellular aging) and lose their ability to proliferate and kill HIV-infected CD4 T-cells.
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