cytotoxic T cell

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cytotoxic T cell

cytotoxic T cell

A CD8+ T lymphocyte that can destroy microorganisms directly through the release of perforin and proteolytic enzymes. These cells are particularly important in the defense against viruses, rejection of allografts, and, possibly, new malignant cells. Synonym: CD8 cell; cytotoxic cel; killer T cell
See also: cell
References in periodicals archive ?
Melief, "Specific T helper cell requirement for optimal induction of cytotoxic T lymphocytes against major histocompatibility complex class II negative tumors," The Journal of Experimental Medicine, vol.
Savoldo et al., "Genetic manipulation of tumor-specific cytotoxic T lymphocytes to restore responsiveness to IL-7," Molecular Therapy, vol.
Ricciardi, "Retroviral transduction of protein kinase C-[gamma] into cytotoxic T lymphocyte clones leads to immortalization with retention of specific function," The Journal of Immunology, vol.
Ying, "Molecular and functional analysis of tyrosinase-related protein (TRP)-2 as a cytotoxic T lymphocyte target in patients with malignant glioma," Journal of Immunotherapy, vol.
Functionally inert HIV-specific cytotoxic T lymphocytes do not play a major role in chronically infected adults and children.
ENV-specific cytotoxic T lymphocyte responses in HIV seronegative health care workers occupationally exposed to HIV-contaminated body fluids.
HLA proteins attach to antigens (such as virus particles) within an infected cell and then display the antigens at the cell surface to induce the destruction of the infected cell by cytotoxic T lymphocytes. Several studies have found certain subtypes and combinations of these HLA molecules associated with LTNPs.
Memory and distribution of virus-specific cytotoxic T lymphocytes (CTLs) and CTL precursors after rotavirus infection.
Rotavirus-specific cytotoxic T lymphocytes passively protect against gastroenteritis in suckling mice.
HIV-1 induces cytotoxic T lymphocytes in the cervix of infected women.
Dorothee et al., "Cutaneous T cell lymphoma reactive CD4+ cytotoxic T lymphocyte clones display a Th1 cytokine profile and use a Fas-independent pathway for specific tumor cell lysis," Journal of Investigative Dermatology, vol.
Kiley and her colleagues at the Food and Drug Administration in Bethesda, Md., and George Washington University in Washington, D.C., are studying the action of cytotoxic T lymphocytes, cellular immune responders that attack foreign or infected cells.
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