Yamaura et al., "Establishment of interleukin 2 dependent cytotoxic T lymphocyte
cell line specific for autologous brain tumor and its intracranial administration for therapy of the tumor," Journal of Neuro-Oncology, vol.
The cytotoxic T lymphocyte
associated antigen-4 (CTLA-4) is expressed on T lymphocytes and inhibits the T-cell responses (2).
Vaccinia virus-specific CD8+ cytotoxic T lymphocytes
Memory and distribution of virus-specific cytotoxic T lymphocytes
(CTLs) and CTL precursors after rotavirus infection.
Fujita, "Granule exocytosis, and not the Fas/Fas ligand system, is the main pathway of cytotoxicity mediated by alloantigen-specific CD4+ as well as CD8+ cytotoxic T lymphocytes
in humans," Blood, vol.
The activation of PD-1/PD-L1 pathways inhibits the infiltration of cytotoxic T lymphocytes
into tumor tissue to kill cancerous cells.
Nieto et al., "CD8 down-regulation on cytotoxic T lymphocytes
of patients with endometrioid endometrial carcinomas," Human Pathology, vol.
The binding of classical cytotoxic T lymphocytes
to their target cell is ensured by the interaction of TCR on the lymphocyte surface with the antigen in the context of MHC class I or II on the surface of the target cell.
Induction of cytotoxic T lymphocytes
from peripheral blood of human histocompatibility antigen (HLA)-A31(+) gastric cancer patients by in vitro stimulation with antigenic peptide of signet ring cell carcinoma.
The clonally expanded population of CD4+ cytotoxic T lymphocytes
in both the peripheral blood and the fibrotic lesions of IgG4-RD patients suggests that these cells are central to the disease.
Hammer et al., "Treatment of solid organ transplant recipients with autologous Epstein Barr virus-specific cytotoxic T lymphocytes
(CTLs)," Blood, vol.
Two opposite populations could be identified among TIL: anticancer lymphocytes (cytotoxic T lymphocytes
, CTLs): CD4+, CD8+, NK cells, and regulatory T cells (Tregs: CD4+/CD25+/Foxp3+ cells) as well as lymphocytes with CTLA-4 expression.