Anikin, PhD Biology, the chief researcher from Saint-Petersburg State Research Institute of Oncology, the results from pre-clinical trials initiated by Meabco A/S to study the interaction of its new proprietary ligand BP-Cx-1 with cytostatics may well open an entirely new perspective for wider use of cis-platin as a first line anti-cancer therapeutic.
Development of a new "universal" ligand, however, which could successfully interact with cytostatics enhancing their safety as well as efficacy, is considered as highly perspective.
The pre-clinical tests are being conducted with various groups of cytostatics (alkylating agents, antimetabolites, plant alkaloids, etc) with promising results; e.
Table I: Classification of cytostatics according to carcinogenic effect (IARC and EU Directive 67/548, Annex VI) Category Carcinogenic Effect on People Examples Category 1 Carcinogenic: Substances with a known Cyclophosphamid carcinogenic effect on people.
Any work with cytostatics requires the effective protection of workers from the effect of such drugs, which can have various carcinogenic, mutagenic and reprotoxic outcomes.
Cytostatics are used as drugs in cancer therapy (chemotherapy) to inhibit the multiplication of tumour cells and are also increasingly being used to treat other diseases.
To prevent staff exposure while handling cytostatics, a range of appropriate precautions must be taken.
To be suitable for dealing with cytostatics, such clothing must also be comfortable to wear, it must have good electrostatic charge derivation and sterilization must be possible.
If, for instance, Class A cleanroom requirements (a cytostatics workstation) are to be met in a Class B cleanroom (location of the workstation), then--according to Carstens--this standard can be fulfilled more easily with a combination of an overall, boots and hood than with a gown, bonnet and cleanroom shoes.