cytopathic effect


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cy·to·path·ic ef·fect

degenerative changes in cells (especially in tissue culture) associated with the multiplication of certain viruses; when, in tissue culture, spread of virus is restricted by an overlay of agar (or other suitable substance) the cytopathic effect may lead to formation of plaque.

cytopathic effect

The characteristic changes which occur in virally-infected cells in tissue culture, which provides a presumptive means of identifying viruses obtained from a clinical specimen—e.g., adenovirus produces grape-like clusters in HEK cells; rhinovirus produces irregular, rounded “dew drop” changes in culture cells; rubella is diagnosed by exclusion, as it interferes with the CPE of other viruses.
References in periodicals archive ?
The activity of each propolis is reflected in the decrease in the cytopathic effect in relation to the exposure time and the concentration at which they are used in the tests (Schnitzler et al.
The plates were incubated at 37[degrees]C and scored for cytopathic effect daily for 7 to 14 days before terminating the readings.
By means of light and transmission electron microscopy we present some observations on the morphology of this amoeba isolated from a case of keratitis as well as its cytopathic effect on MDCK epithelial cell monolayers.
The infected RD cells were observed for the cytopathic effect (CPE) or harvested at eight-hour intervals post infection to determine the number of viral RNA copies by quantitative RT-PCR (qRT-PCR).
Hepatocyte steatosis is a cytopathic effect of hepatitis C virus genotype 3.
Tissue culture flasks were refed with growth medium after 30 minutes and reincubated at 37degC till a good cytopathic effect (CPE) of the virus was obtained.
No viral cytopathic effect was noted in this specimen.
The assay is performed by exposing cell monolayers to stool filtrates, and observing the cells for evidence of cytopathic effect. The possible C.
The diagnosis of CMV is established by the identification of viral cytopathic effect (intranuclear inclusions) in gastrointestinal mucosal biopsies by routine haematoxylin-eosin (H&E) stains [7].
We suspected a malignancy, but histopathology of biopsy specimens revealed that the mass exhibited the classic signs of the HSV cytopathic effect, including the presence of intranuclear inclusion bodies, ballooning degeneration of epithelial cells, and a ground-glass appearance of some nuclei.