KRT10

(redirected from Cytokeratin-10)

KRT10

A gene on chromosome 17q21 that encodes a type-I (acidic) member of the cytokeratin family, which belongs to the superfamily of intermediate filaments, that with actin microfilaments and microtubules forms the epithelial cell cytoskeleton.

Molecular pathology
KRT10 mutations cause epidermolytic hyperkeratosis.
References in periodicals archive ?
Localization of cytokeratin-14 in the basal layer and presence of cytokeratin-10 in the supra-basal layers verified an anatomically correct differentiation of the epidermis.
Physiological differentiation was confirmed by immunohistological staining, showing a physiological location of cytokeratin-14 in the basal layer and cytokeratin-10 in the suprabasal layers (Fuchs, 2009).
Positive binding of primary antibodies against collagen type IV (Col IV), cytokeratin-14 (CK-14), cytokeratin-10 (CK-10), and filaggrin (filagg.