cytokeratin


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Related to cytokeratin: cytokeratin 18, cytokeratin 20, cytokeratin 7

ker·a·tin

(ker'ă-tin),
Collective name for a group of proteins that form the intermediate filaments in epithelial cells. Keratins have a molecular weight between 40 kD and 68 kD and are separated one from another by electrophoresis and isoelectric focusing; thus separated, they are sequentially numbered from 1-20, and also subdivided into low, intermediate, and high molecular weight proteins. According to their isoelectric mobility they are either acidic or basic. In general, each acidic keratin protein has its basic equivalent with which it is paired to form the intermediate filaments; some keratin proteins, however, occur unpaired. Various epithelial cells contain different keratin proteins, in a tissue-specific manner. Antibodies to keratin proteins are widely used for histologic typing of tumors, and are especially useful for distinguishing carcinomas from sarcomas, lymphomas, and melanomas.
Synonym(s): ceratin, cytokeratin
[G. keras (kerat-), horn, + -in]

cytokeratin

A global term for the family of intermediate filament proteins of epithelial origin; the pattern of cytokeratins (CKs) expressed may help differentiate colorectal from lung carcinomas based on low and high molecular weight types.

ker·a·tin

(ker'ă-tin)
A scleroprotein or albuminoid present in hair and nails; it contains a relatively large amount of sulfur, is insoluble in gastric juice, and is sometimes used for coating tablets that are intended to be dissolved only in the intestine.
Synonym(s): cytokeratin.
[G. keras (kerat-), horn, + -in]

cytokeratin

(sīt″ŏ-ker′ăt-ĭn) [ cyto- + keratin],

CK.

Any of the intermediate-sized filament proteins found in epithelial cells. Antibodies against CKs are used to detect specific cell types. The detection of unique CKs helps in the immunohistochemical identification of the origin of specific cancers.
References in periodicals archive ?
Patchy expression of cytokeratin 5/6 (clone D5/16B4) (original magnification X40).
The expression of cytokeratin, vimentin, integrin[[alpha].sub.v][beta]3, and LIF in the VEGF-BMSC group and BMSC group was significantly stronger than those of the control group and were slightly weaker than those of the sham operation group without significance.
Immunohistochemical staining was performed using rabbit monoclonal cytokeratin 19 antibody.
Herrmann et al., "Diagnostic and prognostic role of plasma levels of two forms of cytokeratin 18 in patients with non-small-cell lung cancer," European Journal of Cancer, vol.
[19] reported that cytokeratin immunostaining can help distinguish them; a cytokeratin 7-/cytokeratin 20+ immunophenotype was seen in 94% of the metastatic colonic tumors, 5% of the mucinous carcinomas, and none of the endometrioid or serous tumors.
Ewing's sarcoma/Primitive Neuroectodermal Tumors (PNET) can pose serious diagnostic challenge in terms of their diverse immunoprofile such as cytokeratin, neuroendocrine marker and occasional S100 positivity in tumor cells.
The tumour cells showed patchy positivity for cytokeratin 7.
(10,11) These properties include severe destruction of the elbow joint, a biphasic pattern with nonepithelial and epithelial-like components and a few tumor cells with both vimentin and cytokeratin, and a defective basal membrane on electron microscopy.
The immunohistochemical staining was positive to wide spectrum of antigens: cytokeratin, cytokeratin 7 and carcinoembryonic antigen (CEA) (Figs.
To determine their etiology, we developed a double immunofluorescence (dIF) assay with a polyclonal antibody against WU-VP1 (2), designated NN-Ab01, and a monoclonal antibody against cytokeratins (#M3515; Dako, Carpinteria, CA, USA).
The immunohistochemistry test showed positive immunoreactivity for cytokeratin, being moderately cytoplasmic and diffused in neoplastic cells (Figure 2C, 2E).