cytochrome c

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cy·to·chrome c

(sī'tō-krōm), [MIM*123970]
The mobile cytochrome that transports electrons from Complex III to Complex IV of the respiratory chain.

CYCS

A gene on chromosome 7p15.3 that encodes cytochrome c, an electron carrier protein, which transfers electrons from the heme group of the cytochrome c1 subunit of cytochrome reductase to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. CYCS plays a role in apoptosis by suppressing anti-apoptotic members or by activating pro-apoptotic members of the Bcl-2 family, leading to altered mitochondrial membrane permeability and the release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 activates caspase-9, which then accelerates apoptosis by activating other caspases.

Molecular pathology
Defects in CYCS cause thrombocytopaenia type 4.
References in periodicals archive ?
Cytochrome-c Gene based analysis: A total of sixteen polymorphisms were identified in cytochrome-c gene of Boselaphus tragocamelus as given in Table 3.
Mitochondrial cytochrome-b, cytochrome-c and d-loop region (three genes combined sequence) based analysis: Sequence of three genes (cytochrome-b, cytochrome-c and d-loop) were combined and multidimensional scaling plot was generated.
Polymorphisms in cytochrome-c gene of Boselaphus tragocamelus.
Kadenbach, "Tissue-specific regulation of bovine heart cytochrome-c oxidase activity by ADP via interaction with subunit VIa," Proceedings of the National Academy of Sciences of the United States of America, vol.
Richman et al., "Cardiac dysfunction in mice lacking cytochrome-c oxidase subunit VIaH," American Journal of Physiology.