methemoglobin reductase

(redirected from Cytochrome-b5 reductase)

met·he·mo·glo·bin re·duc·tase

a flavoenzyme catalyzing the reduction of methemoglobin to hemoglobin in the red blood cell.
Farlex Partner Medical Dictionary © Farlex 2012

methemoglobin reductase

An enzyme found in significant amounts in erythrocytes that catalyzes the reduction of methemoglobin in conjunction with the coenzyme nicotine adenine dinucleotide phosphate and other enzymes.
See also: methemoglobin
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
However, its concentration is reduced to less than 1% by the cytochrome-b5 reductase enzyme system; namely, the intracellular MetHb reductive system.
Infants are more at risk for developing methemoglobinemia as fetal hemoglobin is more easily oxidized and their level of cytochrome-b5 reductase does not reach adult values until roughly 4 months of age [9].
(2-) Nussenzveig RH, Lingam HB, Gaikwad A, Zhu Q, Jing N, Prchal JT (2006): A novel mutation of the cytochrome-b5 reductase gene in an Indian patient: the molecular basis of type I methemoglobinemia.
* the NADH-dependent cytochrome-b5 reductase pathway (active under physiological conditions)