CYP17A1

(redirected from Cytochrome P450c17)

CYP17A1

A gene on chromosome 10q24.3 that encodes a member of the cytochrome P450 superfamily of enzymes, which catalyse reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. CYP17A1 localises to the endoplasmic reticulum and has 17 alpha-hydroxylase and 17, 20-lyase activities; it is a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens and oestrogens.

Molecular pathology
CYP17A1 mutations are associated with isolated steroid-17 alpha-hydroxylase deficiency, 17-alpha-hydroxylase/17, 20-lyase deficiency, pseudohermaphroditism and adrenal hyperplasia.
References in periodicals archive ?
Some studies have focused on the ultrastructure and morphology of the different cell types present in each layer of the adrenal cortex and medulla during intrauterine development and the immunolocalization of steroidogenic enzymes, especially that responsible for androgens production, as cytochrome P450c17 in species of wild mammals (Quinn et al.
The aims of present study were compare the morphometric data between left and right adrenal of males and females; perform a histological, scanning and transmission electron microscopy study showing tissue constitution of glands; finally, in order to define the presence and correct site of the cytochrome P450c17 expression in adrenal glands, immunohistochemical study of this enzyme was performed.
Then, the samples were incubated with primary antibodies anti-mouse/rabbit cytochrome P450c17 (donated by Prof.
Enzyme cytochrome P450c17 in cells of fasciculate and reticular zones was immunolocalized, but was not found in the glomerular zone and medulla.
In rats and Balb/c mice, the cytochrome P450c17 is absent in adrenal and therefore the authors suggest that this organ does not contribute to production of androgens (van-Weerden et al.
Further studies of adrenal glands of SYT cavies are required in order to describe which hormones are produced by the enzyme cytochrome P450c17, since this enzyme participates in the synthesis of 17-hydroxy-pregnenolone (pregnenolone-derived), 17-hydroxy-progesterone (progesterone-derived) and the androgen hormones dehydroepiandrosterone (DHEA) and androstenedione (Praporski et al.
Right adrenal was more cranially positioned than left adrenal; dimensions of right adrenal was larger than left adrenal for both male and female; when compared male and female body and adrenal measurements no differences were found; the morphology of cells and different amounts of lipid droplets may be related to the different demands of steroid hormones production, related to each zone of the adrenal cortex; and, the cytochrome P450c17 immunolocalization in fasciculate and reticular zone may be related with synthesis of 17-hydroxy-pregnenolone, 17-hydroxy-progesterone, dehydroepiandrosterone or androstenedione.
17OHD has an autosomal recessive heritage and cytochrome P450c17 enzyme gene locus is 10q24-q25.
Cytochrome P450c17 (steroid 17a-hydroxylase/17,20 lyase): cloning of human adrenal and testis cDNAs indicates the same gene is expressed in both tissues.
Cytochrome P450c17 has two enzyme activities, 17-alpha-hydroxylase and 17,20-lyase.