cytochrome P450

(redirected from Cytochrome P450 monooxygenase)

CYP11A1

A gene on chromosome 15q23-q24 that encodes a member of the cytochrome P450 superfamily of enzymes, which catalyse reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. CYP11A1 localises to the mitochondrial inner membrane and catalyses the conversion of cholesterol to pregnenolone, the first and rate-limiting step in the synthesis of the steroid hormones.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

cytochrome P450

Abbreviation: CYP
A group of enzymes present in every type of cell in the body except red blood cells and skeletal muscle cells. They are important in metabolizing substances normally present in the body such as steroids, fat-soluble vitamins, fatty acids, prostaglandins, and alkaloids. The P450 enzymes also detoxify drugs and a great number of environmental pollutants, such as carcinogens present in tobacco smoke and charcoal-broiled meat, polychlorinated biphenyls, and dioxin. Specialized types of cytochrome P450 are involved in the synthesis of nitric oxide.
See also: cytochrome
Medical Dictionary, © 2009 Farlex and Partners

cytochrome P450

A family of enzymes responsible for the detoxification and elimination of foreign substances including many drugs by hydroxylation and increasing their solubility. The group has been intensively studied because mutations of the cytochrome P450 gene have been found to be associated with a number of diseases including Addison's disease, liver cancer and Parkinson's disease. Cytochrome P450 can also interfere with drug treatment. Selective inhibitors of aromatase-specific cytochrome P450 have been developed to assist in the treatment of breast cancer.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
References in periodicals archive ?
McRee, "Mammalian microsomal cytochrome P450 monooxygenase: structural adaptations for membrane binding and functional diversity," Molecular Cell, vol.
Tuszynski, "Systematic identification and evolutionary analysis of catalytically versatile cytochrome p450 monooxygenase families enriched in model basidiomycete fungi," PLoS One, vol.
Study of new Cytochrome P450 monooxygenase model is of pretty importance to achieve a marked rate enhancement, high substrate specificity, and distinct reaction selectivity under mild oxidation conditions.
We measured the response of 3 detoxifying enzyme systems: general esterase (EST), glutathione S-transferase (GST), and cytochrome P450 monooxygenase (P450).
The work builds on one of the human liver's principal drug-metabolizing enzymes, cytochrome P450 monooxygenase. Earlier work in the project showed that these enzymes are useful as biocatalysts for hydroxylation of benzocycloarenes to regio- and stereospecific alcohols.
Developmental aspects of the hepatic cytochrome P450 monooxygenase system.
Evaluation of the selectivity of in vitro probes and suitability of organic solvents for the measurement of human cytochrome P450 monooxygenase activities.
Das, "Endocannabinoid metabolism by cytochrome P450 monooxygenases," Prostaglandins & Other Lipid Mediators, vol.
Cytochrome P450 monooxygenases belong to a superfamily of haemproteins that play an important role in catalyzing the oxidation of many endogenous and exogenous substances.
Several chapters focus on specific techniques, including use of cytochrome P450 monooxygenases, ionic liquids & supercritical CO2, thiamine-based enzymes, and Baeyer-Villiger monooxygenases.
Cytochrome P450 monooxygenases belong to protein super family of diverse and widely distributed enzymes, which are mainly involved in metabolism of endogenous and exogenous compounds of structurally diverse nature (Hudgson, 1985; Nelson, 1987).
armigera and the enzymatic response of alkaline phosphatase (ALP), glutathione S-transferase (GST), cytochrome P450 monooxygenases and carboxylesterase (Car-E).

Full browser ?