We measured the response of 3 detoxifying enzyme systems: general esterase (EST), glutathione S-transferase (GST), and cytochrome P450 monooxygenase (P450).
Host plant species can passively affect the biochemistry of arthropods and one of the most important effects is on the detoxification enzymes involved in insecticide metabolism, including general esterases, glutathione S-transferases, and cytochrome P450 monooxygenases (e.
The work builds on one of the human liver's principal drug-metabolizing enzymes, cytochrome P450 monooxygenase
Several chapters focus on specific techniques, including use of cytochrome P450 monooxygenases
, ionic liquids & supercritical CO2, thiamine-based enzymes, and Baeyer-Villiger monooxygenases.
Cytochrome P450 monooxygenases belong to protein super family of diverse and widely distributed enzymes, which are mainly involved in metabolism of endogenous and exogenous compounds of structurally diverse nature (Hudgson, 1985; Nelson, 1987).
However, no data is available on its interaction with cytochrome P450 monooxygenases.
Cytochrome P450 Monooxygenases in the Cotton Bollworm (Lepidoptera: Noctuidae): Tissue Difference and Induction.
armigera and the enzymatic response of alkaline phosphatase (ALP), glutathione S-transferase (GST), cytochrome P450 monooxygenases
and carboxylesterase (Car-E).
BACKGROUND: Cytochrome P450 monooxygenases (CYP) play an important role in the defense against inhaled toxicants, and expression of CYP enzymes may differ among various lung cells and tissue compartments.
KEY WORDS: cytochrome P450 monooxygenases, metabolism, smoking, transcription factors, xenobiotic metabolizing enzymes.
We investigated the gene expression of 19 cytochrome P450 monooxygenases (CYPs) and 3 flavin-containing monooxygenases (FMOs), as well as uridine diphosphate glucuronosyltransferase (UGT) 2A1 (UGT2A1), epoxide hydrolase (EPHX1), glutathione-Stransferase (GST) A2 (GSTA2), GSTP1, and GSTM1 in lung cells obtained from bronchoalveolar lavage (BAL) fluid and in bronchial biopsies (BBs) of smokers (n = 8) and nonsmokers (n = 10).
In insects, detoxification of xenobiotics is accomplished by 3 multigene families: carboxylesterases (CarE), cytochrome P450 monooxygenases
(P450) and glutathione-S-transferases (GST) (Claudianos et al.