cysteamine


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cysteamine

 [sis-te´ah-mēn″]
a sulfhydryl amine that is part of coenzyme A; it reduces intracellular cystine levels and is used in treatment of nephropathic cystinosis; administered orally.

cys·te·a·mine

(sis-tā'a-mēn),
2-Aminoethanethiol; a sulfhydryl compound used experimentally to produce ulcers in rats and as a radioprotective agent; antidote to acetaminophen.

cysteamine

A stable aminothiol and metabolite of the amino acid cysteine.

Physiologic role
Cysteamine forms coenzyme A by combining with pantothenate and adenosine triphosphate.

Potential therapeutic role
Cysteamine has been in clinical trials for managing Batten disease, cystinosis, non-alcoholic steatohepatitis and Huntington's disease.

cysteamine

Mercaptamine, a drug used to treat NEPHROPATHIC CYSTINOSIS and prescribable only by urological specialists. A brand name is Cystagon.
References in periodicals archive ?
Improved renal function in children with cystinosis treated with cysteamine. N Engl J Med 1993;328:1157-62.
When the cysteamine self-assembled monolayers (SAMs) formed on Au film, the contact angle became 46.720[degrees], which indicated that the cysteamine SAM is terminated with a hydrophilic domain -N[H.sub.2] [25].
A similar trend was found with the treatment of another autophagyinducing drug, cysteamine (see Supplementary Figure 1), which supported our mechanistic finding that CS exposure causes a phagocytic defect in murine macrophages via autophagy-impairment.
Pillai, "Cysteamine attenuates the decreases in TrkB protein levels and the anxiety/depression-like behaviors in mice induced by corticosterone treatment," PLoS One, vol.
Then the pH of the solution was adjusted to 5.5~6.0 and 0.2182 g cysteamine (AET) was added to the solution.
Though recent gene sequencing technology has added an alternative tool for diagnosis (15), the biochemical assay remains the benchmark for evaluating cysteamine dosage levels and compliance.
Effect of cysteamine supplementation of in vitro matured bovine oocytes on chilling sensitivity and development of embryos.
EFFECT OF SUPPLEMENTATION OF MATURATION MEDIUM WITH CYSTEAMINE AND TWO CULTURE MEDIA (KSOMaa and SOF) ON IN VITRO FERTILIZATION OF BOVINE OOCYTES
The program will provide access to Raptor Pharmaceuticals Corp's PROCYSBI[R] (cysteamine bitartrate) for individual patients with nephropathic cystinosis.
Patient is on treatment with oral cysteamine 50 mg/kg QID, Pottasium citrate, Calcitriol, Ferrous sulphate and multivitamins.
It has been reported that other antioxidant such as Beta- mercaptoethanol, cysteine and cystine (Ali et al., 2003), and cysteamine (Gaspmini et al., 2000) added to IVM medium improve the rate of embryos development to the blastocyst stage.