The leading cause for early termination from FORTITUDE-ALS for patients who received placebo was progressive disease; the leading cause for early termination for patients who received reldesemtiv was a decline in cystatin C
based estimated glomerular filtration rate, a measure of renal function.
Estimating glomerular filtration rate from serum creatinine and cystatin C
. N Engl J Med.
is a biomarker recommended for use in GFR calculations because it is easily glomerular-filtered, has a low molecular weight and is not dependent on muscular mass (5,6).
is a small (13 kDa) cysteine proteinase inhibitor, produced by all nucleated cells at a constant rate.
(CysC) is a more sensitive biomarker than serum creatinine or estimated glomerular filtration rate.
THURSDAY, May 3, 2018 (HealthDay News) -- Reduced kidney function, estimated using cystatin C
, is associated with 20-year cumulative incidence of hearing impairment (HI), according to a study published online April 26 in JAMA Otolaryngology-Head & Neck Surgery.
Although the equations are constructed differently, the calculation of both CKD-EPI and MDRD is based on the 2 renal biomarkers: creatinine and cystatin C
In recent years, cystatin C
, a 13-kD proteinase inhibitor, has also been suggested as a novel marker of renal function.
at hour 6 was lower than the value measured at hour 24 (p = 0.0142).
Danielsen, "Serum cystatin C
as a marker ofthe renal function," Scandinavian Journal of Clinical & Laboratory Investigation, vol.
may be a superior marker in critical illness because it is not affected by muscle mass .
Objective: To compare e-GFR estimated by creatinine or cystatin C
based and combined creatinine and cystatin C
based equations in type 2 diabetics in different stages of albuminuria.