cystatin C


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cystatin C

(sĭs′tăt-ĭn)
A cysteine proteinase inhibitor found in the bloodstream in elevated concentrations in patients with impaired kidney function. It is a small protein composed of 120 amino acids (mass 13 kD) that is produced by nucleated cells throughout the body and easily filtered by the glomeruli of the kidneys. It is reabsorbed and catabolized by proximal tubular cells. Because levels of cystatin C do not depend on a patient's age, height, muscle mass, or weight, it is thought to be a better measure of kidney function than the creatinine clearance test, which is most often used to assess renal health.
References in periodicals archive ?
The leading cause for early termination from FORTITUDE-ALS for patients who received placebo was progressive disease; the leading cause for early termination for patients who received reldesemtiv was a decline in cystatin C based estimated glomerular filtration rate, a measure of renal function.
Estimating glomerular filtration rate from serum creatinine and cystatin C. N Engl J Med.
Cystatin C is a biomarker recommended for use in GFR calculations because it is easily glomerular-filtered, has a low molecular weight and is not dependent on muscular mass (5,6).
Cystatin C is a small (13 kDa) cysteine proteinase inhibitor, produced by all nucleated cells at a constant rate.
Cystatin C (CysC) is a more sensitive biomarker than serum creatinine or estimated glomerular filtration rate.
THURSDAY, May 3, 2018 (HealthDay News) -- Reduced kidney function, estimated using cystatin C, is associated with 20-year cumulative incidence of hearing impairment (HI), according to a study published online April 26 in JAMA Otolaryngology-Head & Neck Surgery.
Although the equations are constructed differently, the calculation of both CKD-EPI and MDRD is based on the 2 renal biomarkers: creatinine and cystatin C (3-5).
In recent years, cystatin C, a 13-kD proteinase inhibitor, has also been suggested as a novel marker of renal function.
Cystatin C at hour 6 was lower than the value measured at hour 24 (p = 0.0142).
Danielsen, "Serum cystatin C as a marker ofthe renal function," Scandinavian Journal of Clinical & Laboratory Investigation, vol.
Cystatin C may be a superior marker in critical illness because it is not affected by muscle mass [11].
Objective: To compare e-GFR estimated by creatinine or cystatin C based and combined creatinine and cystatin C based equations in type 2 diabetics in different stages of albuminuria.