cytochrome P450

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CYP11A1

A gene on chromosome 15q23-q24 that encodes a member of the cytochrome P450 superfamily of enzymes, which catalyse reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. CYP11A1 localises to the mitochondrial inner membrane and catalyses the conversion of cholesterol to pregnenolone, the first and rate-limiting step in the synthesis of the steroid hormones.

cytochrome P450

Abbreviation: CYP
A group of enzymes present in every type of cell in the body except red blood cells and skeletal muscle cells. They are important in metabolizing substances normally present in the body such as steroids, fat-soluble vitamins, fatty acids, prostaglandins, and alkaloids. The P450 enzymes also detoxify drugs and a great number of environmental pollutants, such as carcinogens present in tobacco smoke and charcoal-broiled meat, polychlorinated biphenyls, and dioxin. Specialized types of cytochrome P450 are involved in the synthesis of nitric oxide.
See also: cytochrome

cytochrome P450

A family of enzymes responsible for the detoxification and elimination of foreign substances including many drugs by hydroxylation and increasing their solubility. The group has been intensively studied because mutations of the cytochrome P450 gene have been found to be associated with a number of diseases including Addison's disease, liver cancer and Parkinson's disease. Cytochrome P450 can also interfere with drug treatment. Selective inhibitors of aromatase-specific cytochrome P450 have been developed to assist in the treatment of breast cancer.

cytochrome P450

hepatic microsome responsible for biotransformation of local anaesthetic agents into simpler chemical compounds
References in periodicals archive ?
in patients being treated with CYP450 substrates with narrow therapeutic index, perform therapeutic monitoring of effect (e.
5] Efavirenz possesses a long half-life of 40-55 hours [6] and is predominantly metabolised in the liver by the CYP450 enzyme system.
This study includes an in-depth discussion of the CYP450 metabolism of the most common treatment drugs for these conditions and the serious interactions that can arise from certain drug combinations including serotonin syndrome.
24) Silymarin may have pharmacodynamic activity involving the inhibition and induction of CYP450 enzymes, (25) but preclinical studies have produced conflicting results, possibly due to methodological inconsistencies and poor constituent concentrations.
There are conflicting results from various studies on what effect silymarin has on CYP450 enzymes.
Among these, CYP450 2D6 is responsible for oxidative metabolism of up to 25% of medications (5), including a large subset of antidepressants.
All patients had been diagnosed with akathisia/serotonin toxicity (characterized by agitation) and had undergone testing for variant alleles in CYP450 genes (CYP2D6, CYP2C9, CYP2C19).
Table 2: Medications for overactive bladder: Hepatic CYP450 metabolism [Table omitted]
In the vasculature, smooth muscle cells produce 20-hydroxyeicosatetraenoic acid (20-HETE) as a major product of CYP450 metabolism.
Osmetech plc (LSE:OMH), the international molecular diagnostics company, announces that its exclusive CYP450 4F2 biomarker has been included on the leading warfarin dosing website, www.
The most abundant enzyme in the CYP450 system, CYP3A4, metabolizes about 50%-60% of all medicines.
In some instances, residual blood was extracted with the Qiagen Blood Kit for the GeneChip CYP450 assay (Qiagen Inc.