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Related to Cycloxygenase: Cyclooxygenase 2 inhibitors


an activity of the enzyme prostaglandin endoperoxide synthase.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

pros·ta·glan·din en·do·per·ox·ide syn·thase

a protein complex that catalyzes two steps in prostaglandin biosynthesis; the cyclooxygenase activity (which is inhibited by aspirin and indomethacin) converts arachidonate and 2O2 to prostaglandin G2; the hydroperoxidase activity uses glutathione to convert prostaglandin G2 to prostaglandin H2.
Synonym(s): cyclooxygenase
Farlex Partner Medical Dictionary © Farlex 2012


(sī′klō-ŏk′sĭ-jə-nās′, -nāz′)
1. See COX-1.
2. See COX-2.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.


An enzyme, found in most tissues, that helps turn some fatty acids into protaglandins.
Mentioned in: Cox-2 Inhibitors
Gale Encyclopedia of Medicine. Copyright 2008 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
Moreover, activities on 12-lipoxygenase from human platelets and cycloxygenase (COX)-1 and -2 from sheep cotyledons and seminal vesicles, respectively, have been evaluated.
The assays were performed with purified PGHS-1 from ram seminal vesicles for cycloxygenase (COX)-1 and purified PGHS-2 from sheep placental cotyledons for COX-2 as previously described (Fiebich et al., 2005).
Keywords: Kniphofia foliosa; Knipholone; Leukotrienes; 5-Lipoxygenase; 12-Lipoxygenase; Cycloxygenases
Therefore, knipholone showed higher affinity for the 5-LOX pathway than for cycloxygenases and 12-LOX.
Flavonoids similar or identical to the flavonoids in our preparation can also act as inhibitors of the arachidonic acid metabolism with inhibition of cycloxygenase and 5-lipoxygenase or inhibition of thromboxane synthase (Fernandiz and Alcaraz, 1991; Williams et al.
However, it acts by blocking the enzymes such as cycloxygenases COX-1 and COX-2 which plays vital role in reduction of inflammation and pain, & is generated by the prostaglandins.
ROS can result from increased metabolism associated with dysfunctional mitochondria, oncogene activation, or cytokine/growth factor signaling that triggers ROS-producing enzymes: NADPH oxidases, cycloxygenases (COX), and lipoxygenases (LOX).
Acetaminophen inhibits prostaglandin synthesis by inhibiting cycloxygenases and exerts its antipyretic and analgesic effects2.
Inhibitory effects of brown algal phlorotannins on secretory phospholipase a2s, lipoxygenases and cycloxygenases. J.