cyclooxygenase

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Related to Cycloxygenase: Cyclooxygenase 2 inhibitors

cyclooxygenase

 [si″klo-ok´sĭ-jĕ-nās]
an activity of the enzyme prostaglandin endoperoxide synthase.

pros·ta·glan·din en·do·per·ox·ide syn·thase

a protein complex that catalyzes two steps in prostaglandin biosynthesis; the cyclooxygenase activity (which is inhibited by aspirin and indomethacin) converts arachidonate and 2O2 to prostaglandin G2; the hydroperoxidase activity uses glutathione to convert prostaglandin G2 to prostaglandin H2.
Synonym(s): cyclooxygenase

cyclooxygenase

/cy·clo·oxy·gen·ase/ (-ok´sĭ-jen-ās) a component of prostaglandin synthase (q.v.).

cyclooxygenase

(sī′klō-ŏk′sĭ-jə-nās′, -nāz′)
n.
1. See COX-1.
2. See COX-2.

cyclooxygenase

[si′klō·ok′səjĕnās]
an activity of the enzyme prostaglandin endoperoxide synthase.

Cyclooxygenase

An enzyme, found in most tissues, that helps turn some fatty acids into protaglandins.
Mentioned in: Cox-2 Inhibitors
References in periodicals archive ?
The abdominal writhing induced by acetic acid involves the production and release of arachidonic acid metabolites via cycloxygenase (COX) and prostaglandin biosynthesis (Elisabetsky et al.
Moreover, activities on 12-lipoxygenase from human platelets and cycloxygenase (COX)-1 and -2 from sheep cotyledons and seminal vesicles, respectively, have been evaluated.
The assays were performed with purified PGHS-1 from ram seminal vesicles for cycloxygenase (COX)-1 and purified PGHS-2 from sheep placental cotyledons for COX-2 as previously described (Fiebich et al.
Keywords: Kniphofia foliosa; Knipholone; Leukotrienes; 5-Lipoxygenase; 12-Lipoxygenase; Cycloxygenases
Flavonoids similar or identical to the flavonoids in our preparation can also act as inhibitors of the arachidonic acid metabolism with inhibition of cycloxygenase and 5-lipoxygenase or inhibition of thromboxane synthase (Fernandiz and Alcaraz, 1991; Williams et al.
Acetaminophen inhibits prostaglandin synthesis by inhibiting cycloxygenases and exerts its antipyretic and analgesic effects2.
Inhibitory effects of brown algal phlorotannins on secretory phospholipase a2s, lipoxygenases and cycloxygenases.