cyclophilin


Also found in: Acronyms, Encyclopedia, Wikipedia.

cyclophilin

Any of a family of high-affinity cyclosporin A-binding proteins (cyclophilin A [MIM:123840]; cyclophilin B [MIM:123841]; cyclophilin C [MIM:123842]) that catalyse cis-trans isomerisations. Cyclophilin is the trivial name for peptidylprolyl isomerase, EC 5.2.1.8 (peptidylproline cis-trans-isomerase).
References in periodicals archive ?
The Cyclophilin A has been studied in several organisms including P.
Abbreviated list of licensed or late-stage DAAs for HCV infection NS3/NS4A protease NS5A replication NS5B nucleoside/tide inhibitors complex inhibitors polymerase inhibitors --Simeprevir * --Daclatasvir --Sofosbuvir * --Boceprevir * --Ledipasvir --Meracitabine --Telaprevir * --Samatasvir --Asunaprevir --Ombitasvir --Danoprevir (ABT-267) --Faldaprevir --GS-8516 --Sovaprevir --MK-8742 --ABT-450 --GS-9451 --MK-5172 NS5B nonnucleoside Cyclophilin polymerase inhibitors inhibitors --Deleobuvir --Alisporivir --Dasabuvir (ABT-333) --SCY-635 --BMS-791325 --GS-9669 * Licensed by FDA.
In the presence of ApoE4, increased cyclophilin A causes a breakdown of the cells lining the blood vessels in Alzheimer's disease in the same way it does in cardiovascular disease or abdominal aneurysm.
Recruitment of mitochondrial cyclophilin to the mitochondrial inner membrane under conditions of oxidative stress that enhance the opening of a calcium-sensitive non-specific channel.
It was shown that cyclophilin B binds to the HCV NS5B polymerase and stimulates its RNA-binding activity.
The mechanism of action of cyclosporine A involves binding to cyclophilin, an intracellular protein belonging to immunophillin family.
Lead researcher Jeremy Luban points out that owl monkeys make AoT5Cyp, and that the human genome encodes the equivalent of the two components of this fusion protein, namely TRIM5 and cyclophilin A.
SCY-635, a novel cyclophilin inhibitor, represents a new pharmacological class of inhibitors of hepatitis C virus (HCV) replication.
Bourdette reported at the 2008 Society for Neuroscience meeting that deactivating cyclophilin D--a key protein in mitochondria--was crucial to keeping the balance of calcium steady within nerve cells.
Scientists from Columbia University Medical Center blocked the action of a molecule used by mitochondria, called cyclophilin D, which appears to have a role in cell death in the brains of Alzheimer's patients.