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Related to Cyclooxygenase 2 inhibitors: Cyclooxygenase 2 inhibition


an activity of the enzyme prostaglandin endoperoxide synthase.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

pros·ta·glan·din en·do·per·ox·ide syn·thase

a protein complex that catalyzes two steps in prostaglandin biosynthesis; the cyclooxygenase activity (which is inhibited by aspirin and indomethacin) converts arachidonate and 2O2 to prostaglandin G2; the hydroperoxidase activity uses glutathione to convert prostaglandin G2 to prostaglandin H2.
Synonym(s): cyclooxygenase
Farlex Partner Medical Dictionary © Farlex 2012


(sī′klō-ŏk′sĭ-jə-nās′, -nāz′)
1. See COX-1.
2. See COX-2.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.


An enzyme, found in most tissues, that helps turn some fatty acids into protaglandins.
Mentioned in: Cox-2 Inhibitors
Gale Encyclopedia of Medicine. Copyright 2008 The Gale Group, Inc. All rights reserved.
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