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A cyclic dipeptide postulated as occurring in proteins; it does occur in some of the ergot alkaloids.
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In spite of the initial excitement over her proposed model, it was criticized most severely by Linus Pauling who claimed that the cyclol structure was too unstable to exist.
On the basis of this work, Wrinch was awarded a five-year Rockefeller grant, moved to the US, and became well known for her work on X-ray diffraction in crystals and her proposed model of protein structure based on a fabric of interconnected six-sided rings that she called cyclols. Eventually, she proposed that the rings folded into a hollow cage with a hydrophobic interior.