cyclo-oxygenase-2 inhibitor


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cyclo-oxygenase-2 inhibitor (COX-2)

One of a range of drugs similar in action to NON-STEROIDAL ANTI-INFLAMMATORY drugs. A COX-2 inhibitor drug refoecoxib (Vioxx) was withdrawn in September 2004 when it was found to increase the risk of heart attacks and stroke.
References in periodicals archive ?
Dajani EZ, Islam K 2008 Cardiovascular and gastrointestinal toxicity of selective cyclo-oxygenase-2 inhibitors in man Journal of Physiology & Pharmacology 59 117-133
Risk of myocardial infarction in patients taking cyclo-oxygenase-2 inhibitors or conventional non-steroidal anti-in-flammatory drugs: population based nested case control analysis.
Risk of myocardial infarction in patients taking cyclo-oxygenase-2 inhibitors or conventional non-steroidal anti-inflammatory drugs: population based nested case-control analysis.
Solomon et al., Relationship Between Selective Cyclooxygenase-2 Inhibitors and Acute Myocardial Infarction in Older Adults, 109 Circulation 2068, 2068-73 (2004); Julia Hippisley-Cox & Carol Coupland, Risk of Myocardial Infarction in Patients Taking Cyclo-Oxygenase-2 Inhibitors or Conventional Nonsteroidal Anti-Inflammatory Drugs: Population Based Nested Case-Control Analysis, 330 Brit.
The investigators also found a trend toward lower risk of recurrence in patients who reported using cyclo-oxygenase-2 inhibitors. Just 41 patients (4.7%) used rofecoxib or cele-coxib.