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Related to Cyclo-oxygenase: Cyclooxygenase 2 inhibitors


an activity of the enzyme prostaglandin endoperoxide synthase.

pros·ta·glan·din en·do·per·ox·ide syn·thase

a protein complex that catalyzes two steps in prostaglandin biosynthesis; the cyclooxygenase activity (which is inhibited by aspirin and indomethacin) converts arachidonate and 2O2 to prostaglandin G2; the hydroperoxidase activity uses glutathione to convert prostaglandin G2 to prostaglandin H2.
Synonym(s): cyclooxygenase


(sī′klō-ŏk′sĭ-jə-nās′, -nāz′)
1. See COX-1.
2. See COX-2.


An enzyme, found in most tissues, that helps turn some fatty acids into protaglandins.
Mentioned in: Cox-2 Inhibitors
References in periodicals archive ?
Aspirin produces irreversible inhibition of COX; the synthesis of prostaglandins becomes dependent on the production of new cyclo-oxygenase enzyme.
Nonsteroidal antipyretic drugs inhibit prostaglandin synthesis by decreasing cyclo-oxygenase (Dascombe, 1985).
In the past, prostaglandins were thought to arise from a single cyclo-oxygenase (cox) pathway.
The mechanism of action of NANSAIDs and aspirin is mediated by inhibition of prostaglandin synthesis through an interaction with the enzyme cyclo-oxygenase. This bifunctional enzyme exists in two isoforms, COX-1 and COX-2.
(1992) had earlier found that specific inhibitors of the cyclo-oxygenase enzyme (i.e., aspirin and indomethacin) seriously repressed ascosporogenesis in the genus Dipodascopsis.
(10) In human neoplastic cervical epithelial cells, HPV 16 E5, E6 and E7 oncogenes have been shown to induce the inflammatory cyclo-oxygenase (COX)-prostaglandin axis, by elevating expression of the immediate early oncogene COX-2.
In addition, ionising radiation enhances lysosomal enzyme secretion and arachidonate release from membranes through lipo-oxygenase, cyclo-oxygenase and phospholipase activities, thus increasing the inflammatory cell response.
NSAIDs inhibit both isoforms of the enzyme cyclo-oxygenase (COX).
The advent of cyclo-oxygenase (COX-2) inhibitors was to reduce the well-documented GI adverse effects associated with the use of non-selective NSAIDs.
Some were taking a high dose of lumiracoxib, a type of drug known as a cyclo-oxygenase inhibitor.
amazonica, anti-inflammatory activity relied on cyclo-oxygenase inhibition.
While their data from glucose clamp and brachial artery ultrasound are reassuring, many examples demonstrate the hazards of extrapolating patient-oriented outcomes from intermediate physiologic endpoints (eg, measured cyclo-oxygenase blocking activity vs hospitalizations from gastrointestinal hemorrhage).