cyclic peptide

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cy·clic pep·tide

a peptide that forms a ring structure; for example, tyrocidin A, an antibiotic, is a cyclic decapeptide; valinomycin is a cyclic depsipeptide.
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The teams, led by NIHs National Center for Advancing Translational Sciences (NCATS) and University of Tokyo scientists, sorted through more than 1 trillion small protein fragments called cyclic peptides to uncover two that could shut down the enzyme.
The event also offers two pre-conference workshops focusing on the discovery, development and deployment of cyclic peptides, and exploring cell-penetrating peptides as a powerful new tool for cellular research.
Depsipeptides, a class of natural antimicrobial cyclic peptides, which include one or more ester (depside) bonds as part of their amide backbone, have been characterized in many natural environments and show a wide spectrum of biological activity.
Beginning with a comprehensive chapter outlining computational methods in peptide and protein design, it goes on to explore peptidomimetics, design of cyclic peptides, the role of carbohydrates in the process of design, and de novo methods.
HPLC of extracts of selected samples from Lake Ladoga revealed a rather high diversity of toxins, including hepatotoxic cyclic peptides (microcystins), enzyme inhibitors (cytoxins), and numerous unidentified substances (Table 2; Fig.
The reason for doing that is that cyclic peptides are great potential drug leads.
Sensitivity was enhanced substantially without loss of specificity by the use of synthetic cyclic peptides derived from the sequence of human filaggrin with a high content of citrullin [cyclic citrullinated peptides (CCP)] as antigen (13).
The book contains chapters on synthetic advancements in the chemical classes of carbohydrates, macrolides, polyethers, alkaloids, aromatic heterocycles, carboaromatics, terpenes, steroids, enediynes, linear peptides and amino acids, cyclic peptides and cylcodepsipeptides.
At the structural heart of the drugs are rings, called cyclic peptides, that are composed of either six or eight amino acids.
The hepatotoxins produced by cyanobacteria include cyclic peptides called microcystins and nodularins.
The parameters optimized for simple amides were completely unsatisfactory for this and other cyclic peptides we have studied; shifting the position of the chromophore tended to produce unsatisfactory wavelength shifts.
5,942,492, "Cyclic Peptides That Bind To Urokinase-Type Plasminogen Activator Receptor" covers a broad class of cyclic peptides that Angstrom is developing to inactivate or alternatively to target a key receptor involved in the tumor angiogenesis and tumor metastasis.

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