GJA1

(redirected from Cx43)
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GJA1

A gene on chromosome 6q21-q23.2 that encodes an alpha chain of the gap junction protein family, or connexins.

Molecular pathology
GJA1 mutations are associated with oculodentodigital dysplasia and cardiac malformations.

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References in periodicals archive ?

Western blot analysis: Total proteins extracted either from ovaries or GCs in culture were analyzed by western blotting for Cx43 as described by El-Sabban et al.

Immunolocalization of Cx43 in rat ovaries of DES, eCG, hCG, and PCO groups stained with H & E stains (Figure 1, A-E) revealed that Cx43 localized to the GCs of all animal groups (Figure 1, F-J).

Modulation of Cx43 and gap junctional intercellular communication by androstenedione in rat polycystic ovary and granulosa cells in vitro

Cx43 is the principal gap junction constitutive protein in the adult rat ventricular myocardium.

Prolonged QTc-induced arrhythmias and Western blot data showed down-regulation of Cx43 expression in model rats, perhaps producing a slowed conduction.

Antioxidant and cardioprotective effects of Danshensu (3-(3, 4-dihydroxyphenyl)-2-hydroxy-propanoic acid from Salvia miltiorrhiza) on Isoproterenol-induced myocardial hypertrophy in rats

The percentages of zygotes from the Cx43 group, water group and control group died from the microinjection procedure were 21.

The effect of Cx43 dsRNA on target mRNA expression at the blastocyst stage after culture in vitro

Targeted suppression of Connexin 43 in ovine preimplantation embryos by RNA interference using long double-stranded RNA

Cx43 protein was expressed in fetal ovaries and was localized to primordial follicles, the granulosa layer of primary, secondary, and antral follicles, to theca layer of antral follicles, and an area between the ooeyte and granulosa layer.

Effects of nutrient restriction and dietary selenium on expression of gap junctional protein connexin (CX) 43 in fetal ovaries obtained from sheep in late pregnancy; implications for developmental programming

The reduction in total Cx43 levels itself may have only mode rate effect on the conduction velocity.

The structural and electrical remodeling of myocardium in LVH and its impact on the QRS voltage

Cx43 gene expression was also increased at 24 hr, but in marked contrast to Zn, V exposure did not cause an increase in ion channel gene expression (Figure 6B).

Metal particulate matter components affect gene expression and beat frequency of neonatal rat ventricular myocytes

Effect of AA on Cx43 expression in granulosa cells Cx43 is expressed in porcine granulosa cells following activation of follicular development and this expression significantly increased throughout follicular growth and maturation (Melton et al.

Effect of Arachidonic acid on production of laminin and connexin of granulosa cells from chicken pre-hierarchical follicles

Expression of Cx43 was enhanced by FSH treatment for 2 days but decreased by FSH treatment for 3 days.

Gap junctional protien connexin (Cx) 43 expression in cumulus oocyte complex (COC) of ewes treated with follicle stimulating hormone (FSH)

The present data demonstrate that the expression of Cx43 is lower in expanded COC, which suggests that gala junction-mediated communication between cumulus cells and oocytes is diminishing as oocytes reach maturation stage.

Localization of gap junctional protein connexin (Cx) 43 during maturation of the cumulus oocyte complex (COC) of ewes. (Collegiate Communications--Undergraduate)