GJA1

(redirected from Cx43)
Also found in: Acronyms.

GJA1

A gene on chromosome 6q21-q23.2 that encodes an alpha chain of the gap junction protein family, or connexins.

Molecular pathology
GJA1 mutations are associated with oculodentodigital dysplasia and cardiac malformations.

Mentioned in ?

References in periodicals archive ?

On the other hand, within hours and days, Cx43 was shown to be a significant variation in their spatial location and phenotype.

Apoptosis kinetics at reperfusion period in patients with acute ST-Segment Elevation Myocardial Infarction undergoing primary percutaneous coronary intervention and treated with thrombolytic therapy

About 50 [micro]g protein was separated in 12% sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and electrotransferred to PCDF membrane, and incubated with rabbit anti-human Cx43 antibody (1:1000, Santa, USA) at 37[degrees]C for 4 h, with anti-rabbit secondary antibody (1:2500, Sigma, USA) at 37[degrees]C for 2 h.

Mechanism of Regulatory Effect of MicroRNA-206 on Connexin 43 in Distant Metastasis of Breast Cancer

Real-time RT-PCR was performed in triplicate to analyze the expression of Cx43.

Expression of connexin 43 in synovial tissue of patients with rheumatoid arthritis

In summary, mitochondrial functional proteins play critical roles in the production of ROS in IHD: (1) the defective ETC activity, notably of decreased activity of complex I, may form the pathological foundation for mitochondria-derived ROS overload; (2) the disruption of mitochondrial dynamics, especially depressed mitochondrial fusion, will aggravate mitochondrial ROS production; (3) Tom complex may possess important property in regulating oxidative stress, perhaps via influencing the translocation of mitochondrial proteins; (4) the other functional factors, such as MPTP, MCU/MICU1/MICU2, Cx43, and STAT3, play important roles in preserving mitochondrial integrity and function, directly or indirectly through inhibiting ROS overload (Figure 1).

The Role of Mitochondrial Functional Proteins in ROS Production in Ischemic Heart Diseases

1 53 inflammation response miR-126 Promotion of viral SPRED1, LRP6, 55 replication and WRCH1 miR-1 Interference of cardiac Cx43 56 function miR-21 Alleviation of PDCD4 57 CVB3-induced myocarditis miR-21 and Regulation of viral ROP-yt 58 miR-146b pathogenesis miR-21 Enhancement of viral YOD1 and VCL 59 pathogenesis miR-21 Enhancement of viral SPRY1 60 pathogenesis miRNA Verified functions of the Verified Ref.

The role of microRNAs in enteroviral infections

In pigs, we demonstrated that localization of Cx43 is restricted to cumulus cells, with no Cx43 detected in the oocytes, (73) and we used cell fractionation analysis to examine the cellular distribution of CD44 in COCs.

Intraovarian control of selective follicular growth and induction of oocyte maturation in mammals

realmente realizan el efecto de expresion de las Cx43 mas que el propio

El licopeno y su papel en la prevencion del cancer de prostata

However, its breakdown is gonadotropin dependent and occurs by the clustering of Cx43 in lipid raft microdomains of the cells.

Modulation of Cx43 and gap junctional intercellular communication by androstenedione in rat polycystic ovary and granulosa cells in vitro

For amplification of Cx43, we designed primers using the Primer 5.

Targeted suppression of Connexin 43 in ovine preimplantation embryos by RNA interference using long double-stranded RNA

We hypothesized that maternal diet will affect expression of Cx43 in fetal ovaries.

Effects of nutrient restriction and dietary selenium on expression of gap junctional protein connexin (CX) 43 in fetal ovaries obtained from sheep in late pregnancy; implications for developmental programming

Gap junction remodeling and effect of Cx43 reduction

The structural and electrical remodeling of myocardium in LVH and its impact on the QRS voltage

In this study, the interaction between Cx43 (the major cardiac GJ protein) and ZO-1 in rat neonatal cardiomyocytes and HeLa cells was inhibited by a peptide designed to disrupt the binding of Cx43 and ZO-1.

Disruption of connexin43 and ZO-1 interaction alters the size and distribution of gap junctions