GJA1

(redirected from Cx43)
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GJA1

A gene on chromosome 6q21-q23.2 that encodes an alpha chain of the gap junction protein family, or connexins.

Molecular pathology
GJA1 mutations are associated with oculodentodigital dysplasia and cardiac malformations.
References in periodicals archive ?
Mixed brain cells displayed increased protein expression of CX43 at 24 hours as compared to sham and astrocyte-only cultures (p-value<0.0001, Fig.
There are multiple transporters involved in the reprogrammed metabolism PDAC, including GLUT-1, MCT-1 and -4, CD147, and Cx43; all may serve as potential therapeutic targets, particularly when combined with standard therapies.
Overall, in this study, we used six hAMSC isolates: three for analysis of Cx43 mRNA/protein expression and GJIC and another three for analysis of CFTR protein expression/function and paracellular permeability.
Cxs expression (Cx37, Cx40, and Cx43) in the venous system also exhibited the same manner as in the arterial systems, which is a regional variation [50].
The mRNA-specific primer sequences were designed and synthesized as follows: Cx43 forward: 5'-CAACAACCTG GCTGCGAAAA-3'; reverse: 5'-ACCTTGCCGTGCTCTT CAAT-3'.
Growing evidences from both animal experiments and clinical observations indicate that apoptosis, plays a key role in myocardial reperfusion injury.7-11 The role of mitochondrial ion channels such as Bcl-2 in apoptosis is well-documented and, it is also likely that additional ion channels formed by the connexin 43 (Cx43) protein may play a similar role in cardiac myocyte apoptosis.12-25
Background: MicroRNA-206 (miR-206) and connexin 43 (Cx43) are related with the distant metastasis of breast cancer.
Among their encoded proteins, connexin 43 (Cx43) is the most widely distributed, and it has been found in synovial cells and tissue.
Connexin 43 (Cx43) is the major component of gap junctions in the ventricular myocytes, and it is one of the important connexins in the atria.
Thus, neurotrophic (e.g., BDNF, VEGF), synaptotrophic (e.g., NGF), anti-inflammatory (e.g., Il-6, Il-8, and Il-10), antigliotic (e.g., Cx43), antiapoptotic, and proangiogenic neuroregenerative effects are entrained resulting in significant functional neuroregeneration [12-16].
(55) In the mouse model of CVB3-infected VMC, miR-1 measured by real-time PCR was upregulated upon CVB3 infection and its target gene Connexin 43 (Cx43) measured by western blotting was significantly down-regulated.