GJA1

(redirected from Cx43)
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GJA1

A gene on chromosome 6q21-q23.2 that encodes an alpha chain of the gap junction protein family, or connexins.

Molecular pathology
GJA1 mutations are associated with oculodentodigital dysplasia and cardiac malformations.
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Mixed brain cells displayed increased protein expression of CX43 at 24 hours as compared to sham and astrocyte-only cultures (p-value<0.0001, Fig.
HIGH-RATE MECHANICAL INSULT CONTRIBUTES TO ALTERATIONS IN BRAIN CELL SIGNALING AND REACTIVITY
There are multiple transporters involved in the reprogrammed metabolism PDAC, including GLUT-1, MCT-1 and -4, CD147, and Cx43; all may serve as potential therapeutic targets, particularly when combined with standard therapies.
Glucose and Lactate Transport in Pancreatic Cancer: Glycolytic Metabolism Revisited
Overall, in this study, we used six hAMSC isolates: three for analysis of Cx43 mRNA/protein expression and GJIC and another three for analysis of CFTR protein expression/function and paracellular permeability.
Gap Junctions Are Involved in the Rescue of CFTR-Dependent Chloride Efflux by Amniotic Mesenchymal Stem Cells in Coculture with Cystic Fibrosis CFBE41o- Cells
Cxs expression (Cx37, Cx40, and Cx43) in the venous system also exhibited the same manner as in the arterial systems, which is a regional variation [50].
Function of Connexins in the Interaction between Glial and Vascular Cells in the Central Nervous System and Related Neurological Diseases
Influence of ELF-EMFs Treatments on C2C12 Myoblast cx43 Expression and GJIC.
Extremely Low-Frequency Electromagnetic Fields Affect Myogenic Processes in C2C12 Myoblasts: Role of Gap-Junction-Mediated Intercellular Communication
The mRNA-specific primer sequences were designed and synthesized as follows: Cx43 forward: 5'-CAACAACCTG GCTGCGAAAA-3'; reverse: 5'-ACCTTGCCGTGCTCTT CAAT-3'.
miRNA Expression Profile and Effect of Wenxin Granule in Rats with Ligation-Induced Myocardial Infarction
Growing evidences from both animal experiments and clinical observations indicate that apoptosis, plays a key role in myocardial reperfusion injury.7-11 The role of mitochondrial ion channels such as Bcl-2 in apoptosis is well-documented and, it is also likely that additional ion channels formed by the connexin 43 (Cx43) protein may play a similar role in cardiac myocyte apoptosis.12-25
Apoptosis kinetics at reperfusion period in patients with acute ST-Segment Elevation Myocardial Infarction undergoing primary percutaneous coronary intervention and treated with thrombolytic therapy
Background: MicroRNA-206 (miR-206) and connexin 43 (Cx43) are related with the distant metastasis of breast cancer.
Mechanism of Regulatory Effect of MicroRNA-206 on Connexin 43 in Distant Metastasis of Breast Cancer
Among their encoded proteins, connexin 43 (Cx43) is the most widely distributed, and it has been found in synovial cells and tissue.
Expression of connexin 43 in synovial tissue of patients with rheumatoid arthritis
Connexin 43 (Cx43) is the major component of gap junctions in the ventricular myocytes, and it is one of the important connexins in the atria.
Cellular and molecular mechanisms of arrhythmia by oxidative stress
Thus, neurotrophic (e.g., BDNF, VEGF), synaptotrophic (e.g., NGF), anti-inflammatory (e.g., Il-6, Il-8, and Il-10), antigliotic (e.g., Cx43), antiapoptotic, and proangiogenic neuroregenerative effects are entrained resulting in significant functional neuroregeneration [12-16].
First Autologous Cord Blood Therapy for Pediatric Ischemic Stroke and Cerebral Palsy Caused by Cephalic Molding during Birth: Individual Treatment with Mononuclear Cells
(55) In the mouse model of CVB3-infected VMC, miR-1 measured by real-time PCR was upregulated upon CVB3 infection and its target gene Connexin 43 (Cx43) measured by western blotting was significantly down-regulated.
The role of microRNAs in enteroviral infections

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