CVID


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immunodeficiency

 [im″u-no-de-fish´en-se]
a deficiency of immune response or a disorder characterized by deficient immune response; classified as antibody (B cell), cellular (T cell), or combined deficiency disorders. Antibody immunodeficiencies are marked by hypo- or dysgammaglobulinemia, recurrent bacterial otitis media, and sinopulmonary infections. Cellular immunodeficiencies are characterized by recurrent low-grade or opportunistic infections, by graft-versus-host disease or reaction after blood transfusions, and by severe disease after immunization with live vaccines. See also acquired immunodeficiency syndrome.
common variable immunodeficiency (CVID) a heterogeneous group of disorders characterized by hypogammaglobulinemia, decreased antibody production in response to antigenic challenge, and recurrent pyogenic infections, often associated with hematologic and autoimmune disorders. Most patients have normal numbers of circulating B cells but lack plasma cells and appear to have an intrinsic defect of B cell differentiation. However, two other forms are also recognized: that due to a disorder of T lymphocyte regulation and that due to production of autoantibodies against T and B lymphocytes.
severe combined immunodeficiency (SCID) any of several rare congenital diseases, some of autosomal recessive and some of X-linked inheritance, in which both humoral and cell-mediated immunity fail to develop normally and T lymphocytes are absent or nearly so. In some forms, B lymphocytes are also absent. Early diagnosis is essential to prevent opportunistic infections. Persistent diarrhea, chronic mucocutaneous candidiasis, and failure to thrive may occur in infancy. Blood transfusions can result in graft-versus-host disease and routine vaccinations in fatal infection. Unless immune function is restored by a matched-donor bone marrow or fetal tissue transplantation or the patient is kept in complete isolation, the prognosis is poor.

CVID

common variable immunodeficiency.

CVID

CVID

Common variable immune deficiency, see there.
References in periodicals archive ?
A hypothesis was that CVID and selective IgA deficiency syndrome may reflect a common underlying genetic defect because CVID and IgA-D both share clinical features (14), (15).
Beside helper T-cells abnormality, a low number of LGL/NK cells may provide alternative explanation for a finding by Kalha and Sellin that some CVID patients have a lack of proliferative responses to T-cell receptor stimulation and decreased expression IL-2, IL-4, IL-5, and interferon (IFN)-y (4).
Rastad said, adding that her husband's mother has lupus, an autoimmune deficiency disease that could be an indicator of CVID.
Approximately 60% of CVID, XLA, and HIGM patients were admitted at least once due to pneumonia.
A 60-year-old white woman had been previously diagnosed with CVID, and she had been receiving intravenous immunoglobulin (IVIG) therapy once a month for the previous 5 years.
Most clinical immunology centers have published tha date related only with selected patients followed up with a diagnosis of PID and CVID constitues the great majority of antibody deficiencies in contrast to our study (21, 23, 24).
More experience is needed to provide a better understanding of the relationship between CVID and WNV.
In this study, we reviewed 40 cases of CVID, 5 of which were diagnosed in Peking University First Hospital and 35 cases reported in Chinese literatures from 1984 to 2013 which had relatively complete information and confirmed diagnosis.
The occurrence of CS has been reported in individuals with CD, tropical sprue, CVID, and malignancy-related paraneoplastic syndromes.
Negotiations sources said the United States plans not to insist that North Korea announce a CVID commitment, leaving the ''wording'' to Pyongyang as long as Washington can confirm North Korea's intention to scrap its programs completely and can verify the North's doing so under inspections.