Cushing syndrome


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Cush·ing syn·drome

(kush'ing),
a disorder resulting from increased adrenocortical secretion of cortisol (giving clinical picture of Cushing disease), due to any one of several sources: ACTH-dependent adrenocortical hyperplasia or tumor, ectopic ACTH-secreting tumor, or excessive administrations of steroids; characterized by trunkal obesity, moon face, acne, abdominal striae, hypertension, decreased carbohydrate tolerance, protein catabolism, psychiatric disturbances, and osteoporosis, amenorrhea, and hirsutism in females; when associated with an ACTH-producing adenoma, called Cushing disease.
Synonym(s): Cushing basophilism

Cushing syndrome

or

Cushing's syndrome

n.
A group of symptoms, including a puffy face, fat accumulation around the torso, fat loss from legs and arms, and easy bruising, resulting from elevated levels of cortisol in the bloodstream that are caused either by excess production of the hormone ACTH, as from an adrenal or pituitary tumor, or by administration of high doses of corticosteroid hormones. Cushing syndrome caused by a pituitary tumor is called Cushing disease.

Cushing syndrome

Hypercortisolism A condition characterized by excess corticosteroids, due either to an hypersecretion of cortisol by a hyperfunctioning or neoplastic adrenal cortex, or due to exogenous corticosteroids Etiology Exogenous coticosteroid administration; less commonly, pituitary hyperplasia, adenomas, or cancer Clinical Amenorrhea, hirsutism, HTN, impotence, muscular wasting, skin atrophy, neuropsychiatric dysfunction, osteoporosis, truncal–central obesity, weight gain–water retention, moon face, weakness, fatigue, backache, headache, ↑ thirst, ↑ urination, DM, osteoporosis Lab Hypersecretion of cortisol, loss of the usual circadian rhythm of ACTH and cortisol, and loss of suppressibility of cortisol production by administration of dexamethasone; ↑ adrenal androgens suppresses pituitary output of LH and FSH and causes ↓ sperm production or ovulatory failure Management Surgical excision if tumor is ID'd. See Dexamethasone suppression test, Ectopic hormone syndrome. Cf Pseudo-Cushing syndrome.

Cush·ing syn·drome

(kush'ing sin'drōm)
A disorder resulting from increased adrenocortical secretion of cortisol (giving a clinical picture of Cushing disease), due to any one of several sources: adrenocorticotropic (ACTH)-dependent adrenocortical hyperplasia or tumor, ectopic ACTH-secreting tumor, or excessive administration of steroids; characterized by truncal obesity, moon face, acne, abdominal striae, hypertension, decreased carbohydrate tolerance, protein catabolism, psychiatric disturbances, and osteoporosis, amenorrhea, and hirsutism in females; when associated with an ACTH-producing adenoma, called Cushing disease.
Synonym(s): Cushing basophilism.

Cushing,

Harvey Williams, U.S. neurosurgeon, 1869-1939.
Cushing basophilism - Synonym(s): Cushing syndrome
Cushing bone rongeur
Cushing brain depressor
Cushing brain forceps
Cushing brain spatula
Cushing cranial bur
Cushing cranial rongeur forceps
Cushing disease - adrenal hyperplasia (Cushing syndrome) caused by an ACTH-secreting basophil adenoma of the pituitary. Synonym(s): Cushing pituitary basophilism
Cushing dressing forceps
Cushing dural hook
Cushing dural hook knife
Cushing effect - Synonym(s): Cushing phenomenon
Cushing Gigli-saw guide
Cushing nerve retractor
Cushing perforator
Cushing perforator drill
Cushing periosteal elevator
Cushing phenomenon - a rise in systemic blood pressure when the intracranial pressure acutely increases. Synonym(s): Cushing effect; Cushing response
Cushing pituitary basophilism - Synonym(s): Cushing disease
Cushing response - Synonym(s): Cushing phenomenon
Cushing self-retaining retractor
Cushing straight retractor
Cushing syndrome - a disorder resulting from increased adrenocortical secretion of cortisol. Synonym(s): adrenalism; Cushing basophilism; Gallais syndrome; Itsenko-Cushing syndrome
Cushing syndrome medicamentosus - a variable number of the signs and symptoms of Cushing syndrome.
Cushing ulcer
Itsenko-Cushing syndrome - Synonym(s): Cushing syndrome

Cush·ing syn·drome

(kush'ing sin'drōm)
Disorder resulting from increased adrenocortical secretion of cortisol.
References in periodicals archive ?
Cushing syndrome is relatively rare, with only -~-10 cases per 1 million people (7).
The final conclusive diagnosis was Ectopic cushing syndrome secondary to typical carcinoid pulmonary tumour.
Iatrogenic Cushing syndrome due to nasal steroid drops.
Busaidy et al., "Cushing syndrome secondary to ectopic adrenocorticotropic hormone secretion: the University of Texas MD Anderson Cancer Center experience," Cancer, vol.
As James Findling (11) once said, "if you have never missed the diagnosis of ACTH-dependent Cushing syndrome, and you have never been fooled attempting to establish its cause, you should refer your patients with suspected hypercortisolism to somebody who has" (personal communication).
In this collection of ten articles international experts describe their research in adrenal development and disorders, steroidogenic enzymes, adrenal androgens in humans an nonhuman primates, androgen synthesis and its clinical implications, a new form of congenital adrenal hyperplasia, long-term outcomes of prenatal treatment of congenital adrenal hyperplasia, syndromes involving adrenocorticotropin resistance, corticotrophin-independent Cushing Syndrome, and adrenal steroidogenesis and arterial hypertension.
Osteoporosis, truncal obesity, moon face, purple striae, muscle weakness, easy bruising, hirsutism, hyperglycemia, hypokalemia, and hyperlipidemia suggest Cushing syndrome. Labile hypertension, orthostatic hypotension, headache, palpitations, pallor, and diaphoresis suggests pheochromocytoma.
Hyper- and hypo-thyroidism (thyroid hormones) Hypercalcemia (calcium) Hyper- and hyponatremia (sodium) Hypoglycemia (glucose) Hyperlipidemia (lipids) Hypercapnia (carbon dioxide) Kidney failure Liver failure Cushing syndrome Addison's disease Hypopituitarism Remote effect of carcinoma
Ectopic ACTH secretion accounts for 10-20% of ACTH-dependent Cushing syndrome and mostly originates from bronchial or thymic neuroendocrine tumors or small cell lung carcinomas.
Phitayakorn, "Patients' perception on clinical outcome and quality of life after a diagnosis of Cushing syndrome," Endocrine Practice, vol.