SOD1

(redirected from Cu,Zn superoxide dismutase)

SOD1

A gene on chromosome 21q22.11 that encodes a soluble, copper- and zinc-binding cytoplasmic protein, which is responsible for destroying free superoxide radicals in the body, converting natural—but harmful—superoxide radicals to molecular oxygen and hydrogen peroxide.

Molecular pathology
SOD1 mutations have been linked to familial amyotrophic lateral sclerosis.
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References in periodicals archive ?
Human Cu,Zn superoxide dismutase 1 (hSOD1) is an antioxidant enzyme which protects cells against the oxidative by-products of aerobic metabolism through catalyzing the dismutation of superoxides into oxygen and hydrogen peroxide [1-3].
Getzoff, "The role of arginine 143 in the electrostatics and mechanism of Cu,Zn superoxide dismutase: computational and experimental evaluation by mutational analysis," Proteins, vol.
Chiu et al., "Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation," Science, vol.
Isolation of an active and heat-stable monomeric form of Cu,Zn superoxide dismutase from the periplasmic space of Escherichia coli.
A histidine rich metal binding domain at the N-terminus of Cu,Zn superoxide dismutases from pathogenic bacteria.
Shin et al., "Structural, functional, and immunogenic insights on Cu,Zn superoxide dismutase pathogenic virulence factors from Neisseria meningitidis and Brucella abortus," Journal of Bacteriology, vol.