chronic thromboembolic pulmonary hypertension

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chronic thromboembolic pulmonary hypertension

Abbreviation: CTEPH
Pulmonary HTN that results from the migration of blood clots (usually from the lower extremities) into the lungs. Elevated BP in the lungs gradually overloads the right ventricle and causes right-sided heart failure.

Symptoms

Symptoms usually include shortness of breath, esp. during exercise.

Treatment

The disease, when identified, may be treated with surgical removal of blood clots.

See also: hypertension
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
According to the company, the development of the CTEPH Pattern Recognition AI Software will use deep learning methodology to support radiologists by identifying signs of CTEPH in CTPA scans.
In conjunction, the development of the company's CTEPH Pattern Recognition AI Software will use deep learning methodology to support radiologists by identifying signs of CTEPH in CTPA scans.
Regular telephone follow-up was performed in 175 patients with CTEPH until July 2016 at 3 months, 6 months, 12 months, 18 months, 2 years, 3 years, 4 years, 5 years, 6 years, 7 years, 8 years, 9 years, and 10 years after enrollment.
Echocardiography showed normal LV-EF in 77 patients and low reduction in one patient (no coronary heart disease, TAPSE 14 mm) with nsVT and CTEPH (not shown in Table 2).
We found no reports of levosimendan application in RV failure due to CTEPH except for a case of levosimendan use in life-threatening acute pulmonary embolism (6).
CONCLUSIONS: Pulmonary endarterectomy is an effective and potentially curative surgical treatment for patients with severe CTEPH. Medical therapy for this disease is palliative, and ineffective in prolonging life.
The Bosentan Effects in Inoperable Forms of CTEPH (BENEFIT) study randomized patients to treatment with 62.5 mgbosentan b.i.d for 4 weeks, followed by 125 mg b.i.d, for 12 weeks or placebo.
CTEPH is a rare form of pulmonary hypertension and a life-threatening complication of pulmonary embolism in which scar-like tissue forms around unresolved blood clots in the lungs which block or narrow the arteries.
In future studies, it would be interesting to focus on the differences in the mechanism between CTEPH associated with PTE and hypoxic pulmonary hypertension (HPH), due to lung disease and/or hypoxia.
Among the other three patients not confirmed as PAS after CGFB, one was diagnosed as CTEPH and improved dramatically after surgery as followed up for 4 months.
The companies also entered a clinical development collaboration to market and develop a portfolio of soluble guanylate cyclase (sGC) modulators, including Bayer's Adempas (riociguat), which is approved to treat pulmonary arterial hypertension (PAH) and patients with chronic thromboembolic pulmonary hypertension (CTEPH).