cryoglobulinemia

(redirected from Cryroglobulinemia)

cryoglobulinemia

 [kri″o-glob″u-lin-e´me-ah]
the presence of cryoglobulin in the blood, associated with a variety of clinical manifestations including Raynaud's phenomenon, vascular purpura, cold urticaria, necrosis of extremities, bleeding disorders, vasculitis, arthralgia, neurologic manifestations, hepatosplenomegaly, and glomerulonephritis.

cry·o·glob·u·lin·e·mi·a

(krī'ō-glob'yū-li-nē'mē-ă),
The presence of abnormal quantities of cryoglobulin in the blood plasma.

cryoglobulinemia

Primary cryoglobulinemia Hematology A condition caused by proteins that precipitate in vivo on cooling of acral parts, which are often associated with immune complex-related disease; cryoglobulinemia has been divided into 3 clinical forms Clinical Pain, cyanosis, arthralgias, vascular purpuras, cold intolerance, HTN, CHF Lab ↓ C4 and other complement proteins
Cryoglobulinemia
Type I Monoclonal cryoglobulinemia Underlying disease is often malignant; IgG (malignant myeloma), IgM macroglobulinemia or lymphoma/CLL, rarely others (eg IgA nephropathy), benign monoclonal gammopathy
Type II Poly-monoclonal cryoglobulinemia A complex of immunoglobulins, eg mixed IgM-IgG, G-G, A-G or other combinations that may be associated with lymphoreticular disease or connective tissue disease (rheumatoid arthritis, Sjögren syndrome, mixed essential cryoglobulinemia)
Type III Mixed polyclonal-polyclonal cryoglobulinemia Mixed IgG & IgM, ± IgA, due to rheumatoid arthritis, SLE, Sjögren syndrome, EBV, CMV, subacute bacterial infections, poststreptococcal, crescentic and membranoproliferative glomerulonephritides, DM, chronic hepatitis, biliary cirrhosis

cry·o·glob·u·lin·e·mi·a

(krī'ō-glob'yū-li-nē'mē-ă)
The presence of abnormal quantities of cryoglobulin in blood plasma.
Synonym(s): cryoglobulinaemia.

Cryoglobulinemia

Condition in which protein in the blood forms particles in the cold, blocking blood vessels and leading to pain and numbness of the extremities.