Reason: For the development of cryo-electron microscopy
for high resolution structure determination of biomolecules in solution.
Jacques Dubochet, Joachim Frank and Richard Henderson were awarded the prize for their work in developing cryo-electron microscopy
, or cryo-EM, a technique that fires beams of electrons at proteins that have been frozen in solution to deduce the biomolecules' structure.
5 -- The Nobel Prize in Chemistry 2017 has been awarded to Jacques Dubochet, Joachim Frank and Richard Henderson for the development of cryo-electron microscopy
, which both simplifies and improves the imaging of biomolecules.
Contract notice: Supply of cryo-electron microscopy
equipment of high resolution transmission.
Holger Wille, an associate professor of biochemistry, and his colleagues have employed a technique known as cryo-electron microscopy
to reveal the structure of prions in unprecedented detail.
The team's strategy in designing and synthesizing the DNA nanoparticles was also validated using 3-D cryo-electron microscopy
reconstructions by Bathe's collaborator, Wah Chiu at Baylor College of Medicine.
The consortium aims to evaluate the potential of an emerging analytical technique, cryo-electron microscopy
(cryo-EM), for determining three-dimensional (3D) information about protein structures at the molecular level.
In x-ray crystallography, resolution is the highest resolvable peak in the diffraction pattern, while resolution in cryo-electron microscopy
is a frequency space comparison of two halves of the data, which strives to correlate with the x-ray definition.
This segment currently accounts for a market share of more than 64% of the total market share and is envisaged to retain its dominating hold over the market by 2020 owing to the simplicity of the process and its low cost of operation, especially when compared to cryo-electron microscopy
Here, using single-particle cryo-electron microscopy
, Xing Zhang, et al.
At UMass Medical School, researchers are also enthusiastic about the possibilities of the new High Resolution Cryo-Electron Microscopy
facility the school will build with the life sciences grant.
Then, in separate studies, using first cryo-electron microscopy
and then X-ray crystallography, the researchers were able to reveal the structure of the Env trimer, how it assembles and how it interacts with broadly neutralizing antibodies that target HIV.