Crouzon disease

Crou·zon syn·drome

(krŭ-zŏn[h]'), [MIM*123500]

craniosynostosis with broad forehead, ocular hypertelorism, exophthalmos, beaked nose, and hypoplasia of the maxilla; autosomal dominant inheritance, caused by mutation in the fibroblast growth factor receptor 2 gene (FGFR2) on chromosome 10q. Crouzon syndrome with acanthosis nigricans is due to mutation in the fibroblast growth factor receptor 3 gene (FGFR3) on 4p.

Synonym(s): craniofacial dysostosis, Crouzon disease

Farlex Partner Medical Dictionary © Farlex 2012

Crouzon disease

(kroo-zon′)

[Octave Crouzon, Fr. neurologist, 1874–1938]

An autosomal dominantly inherited congenital disease characterized by hypertelorism (widely spaced eyes), craniofacial dysostosis, exophthalmos, optic atrophy, and divergent squint. The disease is one of the craniosynostoses.

Medical Dictionary, © 2009 Farlex and Partners

Crouzon,

Octave, French physician, 1874-1938.

Crouzon disease - craniostosis with widening of the skull and high forehead, ocular hypertelorism, exophthalmos, beaked nose, and hypoplasia of the maxilla. Synonym(s): craniofacial dysostosis

Crouzon-Apert disease - Synonym(s): Apert syndrome

Medical Eponyms © Farlex 2012