crossover trial

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crossover trial

A clinical trial design in which subjects act as their own control and are assigned to receive investigational product and controls in an order determined by randomisations, with a washout period between the two epochs.

crossover trial

A scientific study of a therapeutic agent in which participants are exposed in sequence to the putative cure and subsequently (or previously) to an inactive agent or an agent whose efficacy has been previously established. The participants cross over from one arm of the study to the other and serve as their own control group.

Participants in such trials are usually under the care of a team of physicians and nurses and are closely monitored, often with testing and examinations on a weekly basis. The clinical trial nurse or nurse research specialist has a broad variety of roles, depending on the nature of the investigation. The roles include recruiting and introducing patients to the trial, coordinating their care, gathering data about side effects and tolerance, and, frequently, serving as a principal or collaborative investigator. Trial planning and design, data interpretation and analysis, and assessments of toxicity are all elements of the work. Health insurers and managed care providers may place restrictions on clinical trial coverage. Many states have laws requiring insurers to pay for the routine costs of all or some clinical trials. Patient advocates work with researchers to make sure a clinical trial is relevant, as safe as possible, and accessible to the broadest variety of patients.

Synonym: crossover (2)
See also: trial
References in periodicals archive ?
The four-arm crossover study compares 5 and 10 mg doses of the lingual spray and tablet formulations of zolpidem in 43 adults.
The department is looking for Cavaliers to participate in this blinded, crossover study. The study requires weekly visits for 12 weeks.
We are progressing as planned across our key initiatives, including the launch of Sympazan, the initiation and execution of a crossover study for Libervant, agreeing with the FDA to move forward with the NDA filing process for that asset, as well as the initiation of the Phase 1 Proof of Concept study for AQST-108.'
In conjunction, the company's proposed Phase 1 pharmacokinetic (PK) study is a fully-randomized, single-blind, placebo-controlled four way crossover study that will evaluate safety and the pharmacokinetics of ORMD-0901 compared to placebo and to open label Byetta, a GLP-1 analog, in up to 15 healthy subjects.
An established flock of 18 Hispaniolan Amazon parrots (Amazona ventralis) was used as a model in a crossover study. The treatment group was subjected to the stress of transport, restraint, and common clinical procedures with serial blood samples collected at 20-minute intervals for hematology and corticosterone levels; the control group was sampled at the same intervals.
A randomized, double-blind crossover study reported in Nutrients found an improvement in the ability to recover from mental fatigue among participants who received the carotenoid astaxanthin plus sesamin, an oxidant-reducing lignan found in sesame seeds.
Ali Haider, M.D., from the University of Texas MD Anderson Cancer Center in Houston, and colleagues conducted a randomized controlled crossover study involving 120 patients from a palliative care clinic.
7, 2018 -- A first-of-its-kind double-blind crossover study of children with autism treated with their own cord blood showed the treatment to be safe and suggests possible improvement in socialization.
7, 2018 -- A first-of-its-kind double-blind crossover study of a treatment for children with autism using their own cord blood showed it to be safe and suggests possible improvement in socialization.
In this issue of JNN, Chiu and colleagues (1) report the findings of a randomized controlled crossover study to assess the effectiveness of home-based footbath to reduce insomnia among people with traumatic brain injury (TBI).