It has been suggested that antigens or immune complexes stemming from the gastrointestinal tract in primary Crohn disease travel through the circulatory system and deposit in the skin, creating perivascular granulomatous features seen on microscopic examination of MCD lesions.
(20) Erythema nodosum is one of the most common cutaneous manifestations of Crohn disease and presents microscopically with granulomatous inflammation involving the septae of the subcutis (ie, septal panniculitis) with a mixed inflammatory infiltrate including neutrophils in the acute phase.
A previous diagnosis of Crohn disease may aid in the diagnosis of MCD, although, as previously mentioned, MCD may present without classical gastrointestinal manifestations of Crohn disease.
Metastatic Crohn disease is a rare cutaneous manifestation of Crohn disease.
For Arg702Trp, the odds ratio for Crohn disease was 2.2 (95% CI, 2.0-2.6) for heterozygotes vs noncarriers and 3.2 (95% CI, 2.0-5.1) for homozygotes vs noncarriers (P = 0.13, z-test; Fig.
Evidence of publication bias was found in only a single metaanalysis, the analysis for Gly908Arg in individuals with familial Crohn disease. Subgroup analyses indicated that the magnitudes of the genetic association in the first published studies were slightly overestimated compared with subsequent studies (see Fig.
The present metaanalysis of79 hospital- and population-based case-control studies including 18 727 cases and 17 102 controls for Crohn disease provides the most comprehensive assessment thus far for the association between NOD2 genetic variants and the risk of Crohn disease.
First, in line with previously reported data for Europeans (12, 13), we observed that the 3 different NOD2 genetic variants are not equally important risk factors for Crohn disease. The per-allele risk of Crohn disease was 2.2-fold for Arg702Trp, 2.6-fold for Gly908Arg, and 3.8-fold for Leu1007fsinsC.
In a recent study, intestinal smooth muscle cells were recovered from intestine with Crohn disease
and sustained in culture.
It has been postulated that altered immunologic status associated with Crohn disease and ongoing chronic inflammation predispose patients to develop Hodgkin disease.
In summary, we have described an additional case of primary EBV-associated Hodgkin disease of the ileum in a 38-year-old man with Crohn disease, further supporting the possible association between primary gastrointestinal Hodgkin disease and Crohn disease.
Primary Hodgkin disease of the ileum complicating Crohn disease. Cancer.