Crixivan


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Related to Crixivan: Invirase, Fortovase

indinavir sulfate

Crixivan

Pharmacologic class: Protease inhibitor

Therapeutic class: Antiretroviral

Pregnancy risk category C

Action

Inhibits replication, function, and maturation of human immunodeficiency virus (HIV) protease, an enzyme essential to formation of infectious virus. As a result, further spread of virus is prevented.

Availability

Capsules: 100 mg, 200 mg, 333 mg, 400 mg

Indications and dosages

HIV infection

Adults: 800 mg P.O. q 8 hours

Dosage adjustment

• Mild to moderate hepatic insufficiency secondary to cirrhosis

Contraindications

• Hypersensitivity to drug or its components
• Concurrent use of amiodarone, ergot derivatives, cisapride, pimozide, or oral midazolam, triazolam, alprazolam, alfuzosin, sildenafil

Precautions

Use cautiously in:
• renal or severe hepatic impairment, history of renal calculi
• pregnant or breastfeeding patients
• children.

Administration

• Know that drug is usually given with other antiretrovirals.
• Give with full glass of water on empty stomach 1 hour before or 2 hours after meals.
• If GI upset occurs, give with a light meal.

Don't give concurrently with alfuzosin, amiodarone, sildenafil, cisapride (not available in U.S.), ergot derivatives, midazolam, pimozide, or triazolam.

Adverse reactions

CNS: depression, dizziness, headache, drowsiness, malaise, asthenia

CV: angina, myocardial infarction

EENT: oral paresthesia

GI: nausea, vomiting, diarrhea, abdominal pain or distention, dyspepsia, acid regurgitation, pancreatitis

GU: dysuria, crystalluria, nephrolithiasis or urolithiasis leading to renal insufficiency or failure, interstitial nephritis

Hematologic: anemia, acute hemolytic anemia, increased spontaneous bleeding (in hemophiliacs)

Hepatic: jaundice, hepatic dysfunction, hepatic failure

Metabolic: new onset or exacerbation of diabetes mellitus, hyperglycemia

Musculoskeletal: joint or back pain

Respiratory: cough, dyspnea

Skin: urticaria, rash, pruritus

Other: abnormal taste, increased or decreased appetite, body fat redistribution or accumulation, fever, anaphylactoid reactions

Interactions

Drug-drug.Azole antifungals, delavirdine, interleukins: elevated indinavir blood level, greater risk of toxicity

Cisapride, ergot derivatives, midazolam, pimozide, triazolam: CYP3A4 inhibition by indinavir, leading to increased blood levels of these drugs and dangerous reactions

Didanosine, efavirenz, rifamycins: decreased indinavir effects

Drug-diagnostic tests.Alanine aminotransferase, amylase, aspartate aminotransferase, bilirubin, cholesterol, glucose, triglycerides: increased values

Hemoglobin, neutrophils, platelets: decreased values

Drug-food.Any food: decreased indinavir absorption

Drug-herbs.St. John's wort: decreased indinavir blood level

Patient monitoring

• Assess fluid intake and output to ensure adequate hydration and help prevent nephrolithiasis or urolithiasis.
• Monitor for adverse GI and CNS effects.
• Evaluate liver function test results. Assess for hyperbilirubinemia.
• Monitor cholesterol, glucose, and CBC with white cell differential.

Patient teaching

• Tell patient to take 1 hour before or 2 hours after meals with a full glass of water.
• If GI upset occurs, advise patient to take with a light meal.

Instruct patient to report severe nausea or diarrhea, fever, chills, flank pain, urine or stool color changes, yellowing of skin or eyes, or personality changes.
• Tell patient that drug doesn't cure HIV infection and that its long-term effects are largely unknown.
• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, tests, foods, and herbs mentioned above.

Crixivan

(krĭk′sə-văn)
A trademark for the drug indinavir sulfate.

Crixivan

a trademark for an antiretroviral protease inhibitor (indinavir).

Crixivan®

 Indinavir, see there.

Crixivan

A brand name for INDINAVIR.
References in periodicals archive ?
Once this inmate got to Parchman, he was not allowed Crixivan.
As one woman reported: "My ADAP didn't cover Crixivan.
Part of the information about Merck is drawn from a study in progress (by Louis Galambos and Jane Eliot Sewell) of the research that led to the development of Crixivan.
s major products include Vasotec and Prinivil (angiotensin-converting enzyme inhibitors for high blood pressure and angina), Mevacor and Zocor (cholesterol-lowering agents), Fosamax (osteoporosis), Vioxx (an antiarthritic), Crixivan (HIV/AIDS), Singulair (asthma), and Prilosec (gastro-intestinal disorders).
Viramune, Epivir, Crixivan, Norvir, Zerit--those are just a few of the names.
the side effects of the new drugs redistributed fat deposits in such sites as "the buffalo hump," "the Crixivan stomach," even if these signs were understood only by initiates.
Deeks and colleagues reviewed the records of 136 HIV-infected people who started on protease inhibitors in March 1996, when Crixivan and Norvir, the first two powerful protease inhibitors, came on the market.
Certain antiretrovirals--notably Viread (tenofovir) and Crixivan (indinavir)--may contribute to kidney problems.
Warnings about using the PI Crixivan in HIV-positive pregnant women are published.
Protease Inhibitors Nucleotide Reverse Agenerase (generic name: amprenavir) Transcriptase Inhibitor Crixivan (indinavir) Viread (tenofovir, PMPA) Fortovase (saquinavir) Kaletra (lopinavir plus ritonavir) Nucleoside Reverse Norvir (ritonavir) Transcriptase Inhibitors Viracept (nelfinavir) Combivir (AZT plus 3TC) Epivir (lamivudine, also Nonnucleoside Reverse known as 3TC) Transcriptase Inhibitors Hivid (zalcitabine, ddC) Rescriptor (delavirdine) Retrovir (zidovudine, AZT) Sustiva (efavirenz) Trizivir (abacavir plus AZT plus 3TC) Viramune (nevirapine) Videx (didanosine, ddl) Zerit (stavudine, d4T) Ziagen (abacavir)
Agenerase amprenavir Combivir [AZT+3TC] Crixivan indinavir Epivir lamivudine (3TC) Fortovase saquinavir Hivid zalcitabine (ddC) Kaletra lopinavir/ritonavir Norvir ritonavir Rescriptor delavirdine Retrovir zidovudine (AZT) Sustiva efavirienz Trizivir [abacavir+AZT+3TC] Videx didanosine (ddI) Viracept nelfinavir Viramune nevirapine Viread tenofovir DF Zerit stavudine (d4T) Ziagen abacavir