Crescentic Glomerulonephritis

An uncommon—1/10,000 people—form of acute glomerulonephritis characterised by heavy proteinuria, microaneurysms, HTN
Associations Acute glomerulonephritis, nephrotic syndrome, renal failure, ESRD; CG may be 2º to post-streptococcal GN, infectious endocarditis, sepsis, hepatitis, multisystem disease, cryoglobulinemia, Goodpasture’s disease, relapsing polychondritis, Henoch-Schönlein purpura, SLE, disseminated vasculitis, polyarteritis nodosa, Wegener’s granulomatosis, lung CA, lymphoma, and others, hydrocarbon exposure, or CG may be superimposed on other primary glomerulopathies—e.g., membranoproliferative-mesangiocapillary glomerulonephritis, membranous glomerulonephritis, IgA nephropathy, focal and segmental glomerulosclerosis, anti-glomerular basement membrane antibody disease
Prognosis Without therapy, 80–90% eventually require dialysis
References in periodicals archive ?
Fiber optic bronchoscopy revealed diffuse blood oozing from all pulmonary segments, consistent with pulmonary hemorrhage, and a percutaneous kidney biopsy showed Pauci-immune crescentic glomerulonephritis, which is typical for MPA.
In ANCA vasculitis, there is negative immunoglobulin and complement staining on immunofluorescence (IF) and a necrotizing and crescentic glomerulonephritis with or without larger vessel vasculitis on light microscopy.
A case of Churg-Strauss syndrome with necrotizing crescentic glomerulonephritis accompanied by acute coronary syndrome due to vasospasm.
It has been suggested that the presence of ANCA has a high sensitivity and specificity for so-called pauciimmune necrotizing and crescentic glomerulonephritis (12,14).
13,14,15) These glomeruli may sometimes be difficult to differentiate from fibrous crescents, but cases of crescentic glomerulonephritis were not included in our study.
Crescentic glomerulonephritis associated with rifampicin in a patient co-infected with tuberculosis and human immunodeficiency virus.
The results were reported in last week's American Society for Nephrology meeting by two independent Italian and British teams investigating seliciclib in lupus nephritis and crescentic glomerulonephritis.
Systemic vasculitis, characterized by inflammatory changes in blood vessels, is a general term used for a group of diseases including Wegener's granulomatosis, microscopic polyarteritis, and crescentic glomerulonephritis.
In diseases such as necrotizing, crescentic glomerulonephritis, where there is disruption of Bowman capsule, fibroblasts can migrate from the interstitium into glomeruli and produce interstitial collagens.
Renal involvement is usually seen with necrotizing, crescentic glomerulonephritis and is typically silent, manifesting with silent hematuria.
A kidney biopsy showed acute necrotizing and pauci-immune acute crescentic glomerulonephritis consistent with Wegener granulomatosis (1) (Figure 2).