Crescentic Glomerulonephritis

An uncommon—1/10,000 people—form of acute glomerulonephritis characterised by heavy proteinuria, microaneurysms, HTN
Associations Acute glomerulonephritis, nephrotic syndrome, renal failure, ESRD; CG may be 2º to post-streptococcal GN, infectious endocarditis, sepsis, hepatitis, multisystem disease, cryoglobulinemia, Goodpasture’s disease, relapsing polychondritis, Henoch-Schönlein purpura, SLE, disseminated vasculitis, polyarteritis nodosa, Wegener’s granulomatosis, lung CA, lymphoma, and others, hydrocarbon exposure, or CG may be superimposed on other primary glomerulopathies—e.g., membranoproliferative-mesangiocapillary glomerulonephritis, membranous glomerulonephritis, IgA nephropathy, focal and segmental glomerulosclerosis, anti-glomerular basement membrane antibody disease
Prognosis Without therapy, 80–90% eventually require dialysis
References in periodicals archive ?
Renal prognosis of ANCA-associated crescentic glomerulonephritis in a Chinese cohort has been reported to be different from that of the European Vasculitis Study Group cohort.
Because of the microscopic features, RPGN is also called crescentic glomerulonephritis (GN).
Proteinase-3-antineutrophil cytoplasmic antibody (PR3-ANCA) positive crescentic glomerulonephritis in a patient with Down's syndrome and infectious endocarditis," Nephrology Dialysis Transplantation, vol.
Kidney biopsy was done (Figures 2 and 3) which showed features suggestive of pauci-immune crescentic glomerulonephritis (PICGN).
Mononuclear cell-infiltrate inhibition by blocking macrophage-derived chemokine results in attenuation of developing crescentic glomerulonephritis.
In ANCA vasculitis, there is negative immunoglobulin and complement staining on immunofluorescence (IF) and a necrotizing and crescentic glomerulonephritis with or without larger vessel vasculitis on light microscopy.
A case of Churg-Strauss syndrome with necrotizing crescentic glomerulonephritis accompanied by acute coronary syndrome due to vasospasm.
It has been suggested that the presence of ANCA has a high sensitivity and specificity for so-called pauciimmune necrotizing and crescentic glomerulonephritis (12,14).
The pathology of the disease is highly characteristic and the only other lesions which may come in the differential diagnosis of the condition include the crescentic glomerulonephritis (CresGN) and the cellular variant of FSGS.
crescentic glomerulonephritis due to ANCA-positive vasculitis
Subsequent chapters deal with specific renal diseases such as Anti-GBM disease, membranous nephropathy, lupus nephritis, IgArelated glomerulonephropathies, mesangiocapillary glomerulonephritis, minimal change nephropathy and focal segmental glomerulosclerosis, systemic vasculitis and crescentic glomerulonephritis, tubulointersitial nephritis, other renal disease of immunological interest and therapeutic aspects.