Crescentic Glomerulonephritis

An uncommon—1/10,000 people—form of acute glomerulonephritis characterised by heavy proteinuria, microaneurysms, HTN
Associations Acute glomerulonephritis, nephrotic syndrome, renal failure, ESRD; CG may be 2º to post-streptococcal GN, infectious endocarditis, sepsis, hepatitis, multisystem disease, cryoglobulinemia, Goodpasture’s disease, relapsing polychondritis, Henoch-Schönlein purpura, SLE, disseminated vasculitis, polyarteritis nodosa, Wegener’s granulomatosis, lung CA, lymphoma, and others, hydrocarbon exposure, or CG may be superimposed on other primary glomerulopathies—e.g., membranoproliferative-mesangiocapillary glomerulonephritis, membranous glomerulonephritis, IgA nephropathy, focal and segmental glomerulosclerosis, anti-glomerular basement membrane antibody disease
Prognosis Without therapy, 80–90% eventually require dialysis
References in periodicals archive ?
Crescentic Glomerulonephritis with linear, granular or no deposit on IF OR
ANCA-negative pauci-immune crescentic glomerulonephritis. Nat Rev Nephrol.
Nevertheless, while the prevailing picture in EGPA is ANCA-associated necrotizing crescentic glomerulonephritis, in acute allergic drug-induced interstitial nephritis, the major histologic abnormalities are in the interstitium, which is expanded by a number of inflammatory cells, with the presence of large numbers of eosinophils, as it is seen in this patient.
Renal biopsy showed necrotizing crescentic glomerulonephritis, leading to the diagnosis of microscopic polyangiitis (MPA).
Ethylmalonic encephalopathyassociated with crescentic glomerulonephritis. Metab Brain Dis 2012;27:613-6.
FSGS: focal and segmental glomerulosclerosis; MGN: membranous glomerulonephritis; IgAN: IgA nephropathy; MPGN: membranoproliferative glomerulonephritis; CGN: crescentic glomerulonephritis; MCD: minimal change disease; MesPGN: mesangioproliferative glomerulonephritis; GN: glomerulonephritis.
Terada, "Mesangial proliferative glomerulonephritis, endocapillary proliferative glomerulonephritis, crescentic glomerulonephritis," Journal of Japanese Society of Internal Medicine, vol.
The subjects included patients with FSGS, MCNS, membranous nephropathy, renal amyloidosis, lupus nephritis, membranoproliferative glomerulonephritis, and crescentic glomerulonephritis. After prospective observation for two years, proteinuria decreased to 1 g/day or less in 47.7% of the patients, indicating the usefulness of LDL apheresis.
Ensari et al., "Pauci-immune necrotizing crescentic glomerulonephritis with crescentic and full moon extracapillary proliferation: Clinico-pathologic correlation and follow-up study," Pathology--Research and Practice, vol.
Sehgal, "Case report: poststreptococcal crescentic glomerulonephritis and pulmonary hemorrhage simulating Goodpasture's syndrome," Annals of Allergy, Asthma & Immunology, vol.
Fain, "Rapidly progressive crescentic glomerulonephritis and aneurism with antineutrophil cytoplasmic antibody: Bartonella henselae endocarditis," La Presse Medicale, vol.
Renal biopsy was done on the 4th hospital day and showed an acute necrotizing and crescentic glomerulonephritis, with ten of fourteen glomeruli showing cellular crescents, often in association with areas of fibrinoid necrosis (Figures 1(a) and 1(b)).