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chondroitin polysulfate(trade name),
OsteoarthritisIschemic heart diseaseHyperlipidemiaOsteoporosis Ophthalmic: In combination with sodium hyaluronate, for use as a surgical aid in cataract extraction or lens implantation, and as a lubricant
ClassificationTherapeutic: nonopioid analgesics
May serve as a building block of articular cartilage. May protect cartilage against degradation. May have antiatherogenic properties.
Improvement in osteoarthritis symptoms.
Absorption: 8–18% is absorbed orally.
Metabolism and Excretion: Unknown.
Contraindicated in: Obstetric: Pregnancy and lactation.
Use Cautiously in: Asthma (may exacerbate symptoms); Clotting disorders (may ↑ risk of bleeding); Prostate cancer (may ↑ risk of metastasis or recurrence).
Adverse Reactions/Side Effects
- bleeding (antiplatelet effect)
- allergic reactions
- hair loss
InteractionsUse of chondroitin with anticoagulant and antiplatelet drugs, thrombolytics, NSAIDs, some cephalosporins, and valproates may ↑ risk of bleeding.Herbs with anticoagulant or antiplatelet properties may ↑ bleeding risk when combined with chondroitin, including: anise, arnica, chamomile, clove, dong quai, fenugreek, feverfew, ginger, ginkgo, Panax ginseng, licorice, and others.
Oral (Adults) Osteoarthritis—200–400 mg 2–3 times daily or 1000–1200 mg once daily. Prevention of recurrent myocardial infarction—10 grams daily in 3 divided doses for 3 mo followed by 1.5 grams daily in 3 divided doses as maintenance therapy.
Intramuscular (Adults) Osteoarthritis—50 mg twice weekly for 8 weeks every 4 mo.
Injection (not available in US):
Ophthalmic Drops Rx in combination with sodium hyaluronate (Viscoat):
- Evaluate drug profile before starting therapy with this herbal supplement. If the patient is taking anticoagulants or antiplatelet drugs, avoid use of this herb.
- Monitor pain (type, location and intensity) and range of motion on an ongoing basis as an indicator of drug efficacy.
- Evaluate gastric discomfort and instruct patient to seek out the advice of a health care professional if persistent gastric discomfort occurs.
- Assess for signs of bleeding and discontinue herbal supplement promptly and seek out healthcare professional for follow up.
Potential Nursing DiagnosesChronic pain (Indications)
Impaired physical mobility (Indications)
- Administer with food.
- Advise patients that this herbal supplement is usually taken with glucosamine.
- Caution patients who take aspirin or NSAIDs or other nonprescription medications not to take this herbal supplement without conferring with their health care professional.
- Advise female patients to notify health care professional if pregnancy is planned or suspected or if breastfeeding; avoid use.
- Instruct patients that this medication works by building up cartilage and that this requires that the medication be taken consistently over a period of time. It is not recommended as a supplemental pain medication.
- Improvement in pain and range of motion.
- Reduced need for supplemental or breakthrough pain medication.
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