CREBBP

(redirected from Creb-binding protein)
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CREBBP

A gene on chromosome 16p13.3 that encodes a ubiquitously expressed protein involved in the transcriptional coactivation of various transcription factors. CREBBP acts as a scaffold to stabilise additional protein interactions with the transcription complex; it has intrinsic histone acetyltransferase activity, and acetylates both histone and non-histone proteins.

Molecular pathology
CREBBP mutations cause Rubinstein-Taybi syndrome (RTS); chromosomal translocations of CREBBP are associated with acute myeloid leukaemia.
References in periodicals archive ?
Thus, asparagine hydroxylation allows for complex formation between HIF-1[alpha] and the CREB-binding protein and p300 transcriptional coactivators that in this way also become involved in the transcriptional control of HIF-dependent responses (Freedman et al.
Redox-regulated recruitment of the transcriptional coactivators CREB-binding protein and SRC-l to hypoxia-inducible factor 1[alpha].
Phosphorylated CREB (pCREB) then recruits another transcriptional co-factor called CREB-binding protein (CBP), which contains intrinsic HAT activity.