CREBBP

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CREBBP

A gene on chromosome 16p13.3 that encodes a ubiquitously expressed protein involved in the transcriptional coactivation of various transcription factors. CREBBP acts as a scaffold to stabilise additional protein interactions with the transcription complex; it has intrinsic histone acetyltransferase activity, and acetylates both histone and non-histone proteins.

Molecular pathology
CREBBP mutations cause Rubinstein-Taybi syndrome (RTS); chromosomal translocations of CREBBP are associated with acute myeloid leukaemia.
References in periodicals archive ?
Livingston, "Distinct roles for CREB-binding protein and p300 in hematopoietic stem cell self-renewal," Proceedings of the National Academy of Sciences of the United States of America, vol.
Andresen et al., "The translocation t(8;16)(p11;p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB-binding protein," Nature Genetics, vol.
Phosphorylated CREB (pCREB) then recruits another transcriptional co-factor called CREB-binding protein (CBP), which contains intrinsic HAT activity.
Partial depletion of CREB-binding protein reduces life expectancy in a mouse model of Huntington disease.
The researchers found that dietary restriction induces a transcription factor called CREB-binding protein (CBP), which controls the activity of genes that regulate cellular function.
Thus, asparagine hydroxylation allows for complex formation between HIF-1[alpha] and the CREB-binding protein and p300 transcriptional coactivators that in this way also become involved in the transcriptional control of HIF-dependent responses (Freedman et al.
Recruitment of the histone acetylase CBP (CREB-binding protein) to a promoter contributes to increased transcription (Valapour et al.