Its pipeline includes a Phase 3 candidate to treat type 1 diabetes, a drug that is in Phase 2 clinical trials to treat inflammatory bowel disease and an investigational new drug developed to treat acute coxsackie B
virus infection and the potential prevention or delay in onset of type 1 diabetes.View the full article from NJBIZ at http://www.njbiz.com/article/20180720/NJBIZ01/180729989/oldwick-biopharma-company-raises-64m-in-ipo.
On the contrary, enteroviruses such as Coxsackie B have demonstrated prominent summer-fall seasonality due to proposed driving climate factors such as dew point temperature .
Rhabdomyolysis in Coxsackie B. Rhabdomyolysis from Coxsackie virus is generally rare.
Although their virulence for humans is extremely variable, Coxsackie B infection may cause a wide variety of clinically recognizable diseases, such as pleuritis, myocarditis, pericarditis, pancreatitis, and hepatitis .
This patient had positive antibody titers to six different serotypes of coxsackie B, 1 through 6.
(14) A moderate order association of Coxsackie B with myocarditis has been made by correlation of neutralizing antibodies titres or by isolation of virus from rectal and nasopharyngeal swab with acute myocarditis (Bell and Grist 1968, (15) Freij et al 1970, (16) Smith 1970, (17) Koontz and Ray 1971, (18) Toshima et al 1979.
Bell,  found that 1/3rd cases of pericarditis and % cases of myocarditis were associated with Coxsackie B virus infection.
Clinical features of acute Coxsackie B viral myocarditis.
Six serotypes of coxsackie B
viruses (CBVs) (family Picornaviridae, genus Enterovirus) are recognized: CB1-6.
It is believed the teenager was the victim of the Coxsackie B virus, which can trigger fatal heart problems without warning.
Belinda Linden, a cardiac nurse adviser at the British Heart Foundation, said some people with the Coxsackie B virus suffered flu-like symptoms and then recovered, while others suffered long-term damage to the heart.
Most EVs have been implicated in aseptic meningitis, most notably echovirus (E) 30, 9, 6, and 11 and coxsackie B
virus (CBV) type 5 (2); other serotypes are less frequently associated with neurologic disease.