Rat-to-elephant-to-human transmission of cowpox virus
However, the method perfectly detected and differentiated variola from monkeypox virus (endemic in Africa), from cowpox virus
(endemic in Europe but responsible for only limited cutaneous lesions in immunocompetent people), and also from vaccinia virus, thus helping to ascertain the diagnosis of complications of a smallpox vaccination in clinical practice (e.
Huggins' team exposed several groups of mice to an aerosol of cowpox virus
and simultaneously gave some the HDP-CDV treatment or cidofovir.
Putting a modern spin on the work of English physician Edward Jenner, who used cowpox virus
200 years ago to vaccinate people against smallpox, Kapikian and his colleagues at NIAID employed a weakened rotavirus strain that infects these monkeys.
Orthopoxviruses (family Poxviridae, genus Orthopox-virus) cause several zoonotic diseases worldwide, including diseases caused by monkeypox virus in Africa, cowpox virus
mainly in Europe, and vaccinia virus (VACV) in South America and Asia (1).
As for cowpox virus
, horse and human may be infected from a common source, such as rodents, and not necessarily from each other.
Kaposi sarcoma was suspected initially, but on hospital day 5, a skin biopsy showed large intracellular eosinophilic inclusion bodies pathognomonic for infection with cowpox virus
(family Poxviridae, genus Orthopoxvirus).
The first, which celebrates its 200th anniversary this year, occurred when Edward Jenner demonstrated that inoculations with the cowpox virus
protect humans from the ravages of smallpox.
Additional PCRs and sequencing confirmed zoonotic cowpox virus
(CPXV) with strain designation FIN/K2009.
All known MPXV genomes, including MPXV-TNP, and the genome of cowpox virus
GRI-90 (used as out-group) were truncated to include the sequence information between the first and last coding region for further phylogenetic analysis (MrBayes, v.
Viruses in the family Poxviridae, genus Orthopoxvirus, consist of numerous pathogens known to infect humans, including variola virus (VARV), monkeypox virus (MPXV), cowpox virus
(CPXV), and vaccinia virus (VACV).
cgi) identified cowpox virus
(CPXV; family Poxviridae, genus Orthopoxvirus) in all cases.