Cowden syndrome

(redirected from Cowden's disease)

Cowden syndrome

or

Cowden disease

(koud′n)
n.
An autosomal dominant disorder characterized by the formation of benign growths especially on the skin and mucous membranes and an increased risk of developing malignancies in the breast, thyroid, and other organs. Also called multiple hamartoma syndrome.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

Cowden syndrome

A rare autosomal dominant genodermatosis (OMIM:158350) characterised by multiple hamartomas arising from all three germ cell layers, most prominently from the ectoderm and endoderm, in particular hamartomas of skin and the GI tract (from the stomach to the colon) and an increased risk of cancer (e.g., breast, thyroid (papillary or follicular), uterus and osteosarcoma). Women with Cowden syndrome have up to a 50% lifetime risk of developing breast cancer; 75% have benign breast disease (fibroadenomas, fibrocystic changes).
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

Cowden disease

, Cowden syndrome (kowd'en) [ Cowden, family name of first patient described] Multiple hamartoma.
Medical Dictionary, © 2009 Farlex and Partners

Cowden,

Rachel, the first patient to be described with this condition in 1963.
Cowden syndrome - an autosomal dominant syndrome characterized by multiple trichilemmomas occurring around the mouth, nose, and ears.
Medical Eponyms © Farlex 2012
References in periodicals archive ?
Winans, "Ganglioneuromatosis of the colon and extensive glycogenic acanthosis in Cowden's disease," Digestive Diseases and Sciences, vol.
ANTONIA COWDEN'S DISEASE WHEN Antonia Palmer suffered a series of agonising headaches, she opted to grin and bear it.
It wasn't until the age of 34 that she learned she had Cowden's disease - a rare illness which puts her a higher risk of cancer.
Up to 50% of women with Cowden's disease get breast cancer, and 10% are diagnosed with thyroid cancer, he added.
Up to 50% of women with Cowden's disease get breast cancer, and about 10% are diagnosed with thyroid cancer, he added.
This disease is often associated with a familial (autosomal dominant) hamartoma-neoplasia syndrome called Cowden's disease (CD).
Cowden's disease is a hereditary disorder characterized by oropharyngeal fibrosis and multiple hamartomas with potential malignant changes.
Cowden's disease (multiple hamartoma syndrome), first described in 1963 by Lloyd and Dennis, is a rare autosomal-dominant disease.
To our knowledge, there has been no previous report in the literature of Cowden's disease in which the fibrotic lesions affected a vocal fold.
In view of the constellation of clinical features--oropharyngeal fibrosis and papillary lesions on the pharynx, larynx, lips, left vocal fold, and skin-a diagnosis of Cowden's disease was made.
* Cowden's disease. This condition, also known as multiple hamartoma-neoplasia syndrome, causes hamartomas that involve the skin, intestine, breast, and thyroid.