Cowden's disease

Cowden's disease

Etymology: Cowden, family name of the first recorded case
an autosomal-dominant disorder characterized by hypertrichosis, gingival fibromatosis, facial papules, hemangiomas, and postpubertal fibroadenomatous breast enlargement. Also called hamartoma syndrome.
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Cowden's disease
References in periodicals archive ?
ANTONIA COWDEN'S DISEASE WHEN Antonia Palmer suffered a series of agonising headaches, she opted to grin and bear it.
It wasn't until the age of 34 that she learned she had Cowden's disease - a rare illness which puts her a higher risk of cancer.
Up to 50% of women with Cowden's disease get breast cancer, and about 10% are diagnosed with thyroid cancer, he added.
Cowden's disease is a hereditary disorder characterized by oropharyngeal fibrosis and multiple hamartomas with potential malignant changes.
Cowden's disease (multiple hamartoma syndrome), first described in 1963 by Lloyd and Dennis, is a rare autosomal-dominant disease.
To our knowledge, there has been no previous report in the literature of Cowden's disease in which the fibrotic lesions affected a vocal fold.
In view of the constellation of clinical features--oropharyngeal fibrosis and papillary lesions on the pharynx, larynx, lips, left vocal fold, and skin-a diagnosis of Cowden's disease was made.
These findings confirmed the diagnosis of Cowden's disease.
In addition to Cowden's disease, the differential diagnosis includes neurofibromatosis, amyloidosis, and multifocal idiopathic fibrosis: