Councilman bodies

Councilman bodies

Red-staining dead liver cells found in YELLOW FEVER, HEPATITIS and other serious liver disorders. (William Thomas Councilman, 1854–1933, American pathologist).
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Histologic examination indicated the following for all animals: zonal bridging (largely midzonal and centrilobular) or massive liver necrosis with Councilman bodies, varying degrees of macrovacuolar and microvacuolar steatosis, and pleocellular (mainly lymphohistiocytic) inflammatory infiltrates, accompanied by hemorrhage and hemosiderosis (Figure 2, panels A, B; online Technical Appendix Table 1, https://wwwnc.cdc.gov/EID/article/23/12/17-0685-Techapp1.pdf).
Histopathologic examination of the liver showed extensive necrosis, steatosis, and numerous Councilman bodies compatible with fulminant yellow fever (YF) hepatitis.
Round eosinophilic cytoplasmic structures suggestive of megamitochondria were observed in 2 neonates, mild to moderate steatosis and Councilman bodies (apoptosis) in 3, hepatocyte necrosis in 1 (neonate 7) (online Technical Appendix), and mild periportal lymphocytic inflammation in 1 (neonate 2).
Microscopy examination of postmortem liver biopsies showed histopathologic changes characteristic of YF: midzonal necrosis with a small rim of a few viable periportal and pericentral hepatocytes and centrilobular cells with microsteatosis and eosinophilic degeneration with round, eosinophilic cytoplasmic structures (Councilman bodies).