coumarin

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Related to Coumarins: Tannins, Flavonoids

coumarin

 [koo´mah-rin]
1. a principle extracted from the tonka bean, from which several anticoagulants are derived that inhibit hepatic synthesis of vitamin K–dependent coagulation factors.
2. any of these derivatives.

cou·ma·rin

(kū'mă-rin),
1. A general descriptive term applied to anticoagulants and other drugs derived from dicumarol, a component of the Tonka bean.
2. A fragrant neutral principle obtained from the Tonka bean, Dypterix odorata, and made synthetically from salicylic aldehyde; it is used to disguise unpleasant odors.
[coumarou, native name of Tonka bean]

coumarin

/cou·ma·rin/ (koo´mah-rin)
1. a principle extracted from the tonka bean; it contains a factor, dicumarol, that inhibits hepatic synthesis of vitamin K–dependent coagulation factors, and a number of its derivatives are used as anticoagulants in treating disorders characterized by excessive clotting.
2. any of these derivatives or any synthetic compound with similar activity.

coumarin

(ko͞o′mər-ĭn)
n.
A fragrant crystalline compound, C9H6O2, present in tonka beans and produced synthetically for use as a fragrance. Coumarin has been banned as a food additive in the United States because it can be toxic in large amounts.

cou′ma·ric (-mər-ĭk) adj.

coumarin

[ko̅o̅′mərin]
a class of orally active anticoagulant agents with warfarin as its prototype.
indications It is prescribed for prophylaxis and treatment of thrombosis and embolism.
contraindications Known hypersensitivity to the drug prohibits its use. It is not prescribed to patients who are at risk for hemorrhage or who are pregnant.
adverse effects The most serious adverse reaction is hemorrhage. Many other drugs interact with this drug to increase or decrease its effect.

cou·ma·rin

(kū'mă-rin)
Fragrant neutral principle obtained from the Tonka bean, Dypterix odorata, and also made synthetically from salicylic aldehyde; used to disguise unpleasant odors.

coumarin,

n C9H6O, derived from a variety of sources, including tonka bean and sweet clover; may also be artificially manufactured.
Enlarge picture
Coumarin.

cou·ma·rin

(kū'mă-rin)
A general descriptive term applied to anticoagulants and other drugs derived from dicumarol.

coumarin

1. a principle extracted from the tonka bean, from which several anticoagulants are derived, that inhibits hepatic synthesis of vitamin K-dependent coagulation factors.
2. any of these derivatives.
3. see also dicoumarol.
References in periodicals archive ?
In conclusion, among the coumarin compounds that we successfully synthesized, compounds I c, I d, II c and II d had a strong electron-withdrawing group (-CH2Cl, -Cl, -CN and -CF3) in the phenyl ring with the highest cytotoxic activity against the cancer cell lines tested.
Many heterocyclic compounds have previously been reported to demonstrate antiinflammatory activity [42-47], as well as natural and synthetic coumarins were also found to scavenge reactive oxygen species [36, 37].
Anti-viral evaluation of sesquiterpene coumarins from Ferula assa-foetida against HSV-1.
Some quantitative phenolic compound increased and some phenolic compounds found absent by irradiation treatment in purslane such as catechein, coumarin, and cinnamic.
Conclusion: This pharmacokinetic identification of multiple coumarins of ADR in rats provides a significant basis for better understanding the metabolic mechanism of the herb medicine.
According to the phytochemical investigation of column fractions of petroleum ether extract, the three fractions B and E were selected for the antimicrobial investigation due to the presence of more active constituents such as flavonoids, terpenoids, tannins and alkaloids, coumarin than the other fractions.
Anticoagulant activity of isolated coumarins and toxicity evaluation of Ferulago carduchorum in rats.
Antiinflammatory activities of coumarins isolated from Angelica gigas Nakai on LPS-stimulated RAW 264.
The first part of the volume is organized by chemical class, covering monoterpenes, sesquiterpenes, triterpenes & steroids, essential oils, phenolic compounds, phenylpropanoids, coumarins, flavonoids, quinones & benzophenones, xanthones & anthranoids, lignans & stilbenes, tannins, alkaloids, and ceramides & cerebrosides.
Under the irradiation of ultraviolet (UV) [lambda] > 310 nm), the double bonds, at the 3, 4 position, in coumarins are cleaved to form cyclobu-tane bridges, leading to the dimerization.
Composition of oak Lignin 25% Hemicellulose 25% Cellulose 40% Lignin 15-25% Hemicellulose 23-32% Cellulose 38-50% Extractable components: * ~10% phenolic compounds (tannins, phenols, coumarins, etc.