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Related to Coumadin: INR, heparin


trademark for preparations of warfarin sodium, an anticoagulant.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

warfarin sodium

Apo-Warfarin (CA), Coumadin, Gen-Warfarin (CA), Jantoven, Marevan (UK), Novo-Warfarin (CA), Taro-Warfarin (CA)

Pharmacologic class: Coumarin derivative

Therapeutic class: Anticoagulant

Pregnancy risk category X

FDA Box Warning

• Drug may cause major or fatal bleeding. Bleeding is more likely during starting period and with higher dosage (resulting in higher International Normalized Ratio [INR]). Monitor INR regularly in all patients. Those at high risk for bleeding may benefit from more frequent INR monitoring, careful dosage adjustment, and shorter duration of therapy. Instruct patients about measures to minimize risk of bleeding and advise them to immediately report signs and symptoms of bleeding.


Interferes with synthesis of vitamin K-dependent clotting factors (II, VII, IX, and X) and anticoagulant proteins C and S in liver


Injection: 5.4 mg/vial (2 mg/ml when reconstituted)

Tablets: 1 mg, 2 mg, 2.5 mg, 3 mg, 4 mg, 5 mg, 6 mg, 7.5 mg, 10 mg

Indications and dosages

Venous thrombosis; pulmonary embolism; atrial fibrillation; myocardial infarction (MI); thromboembolic complications of cardiac valve placement

Adults: Initially, 2.5 to 10 mg P.O. or I.V. daily for 2 to 4 days, then adjusted based on prothrombin time (PT) or International Normalized Ratio (INR). Usual maintenance dosage is 2 to 10 mg P.O. daily.

Dosage adjustment

• Elderly or debilitated patients

Off-label uses

• Acute coronary syndrome

• Intracoronary stent placement

• Prevention of catheter thrombosis


• Hypersensitivity to drug

• Uncontrolled bleeding

• Open wounds

• Severe hepatic disease

• Hemorrhagic or bleeding tendency

• Cerebrovascular hemorrhage

• Cerebral aneurysm or dissecting aorta

• Blood dyscrasias

• Pericarditis or pericardial effusion

• Bacterial endocarditis

• Malignant hypertension

• Recent brain, eye, or spinal cord injury or surgery

• Lumbar puncture and other procedures that may cause uncontrollable bleeding

• Major regional or lumbar block anesthesia

• Threatened abortion, eclampsia, preeclampsia

• Unsupervised senile, alcoholic, or psychotic patients

• Pregnancy, females of childbearing potential


Use cautiously in:

• cancer, heparin-induced thrombocytopenia, moderate to severe renal impairment, moderate to severe hypertension, infectious GI disease, known or suspected deficiency in protein C-mediated anticoagulant response, polycythemia vera, vasculitis, severe diabetes mellitus

• indwelling catheter use

• history of poor compliance

• elderly or debilitated patients

• breastfeeding patients

• children younger than age 18 (safety and efficacy not established).


Be aware that warfarin is a high-alert drug.

• Know that I.V. form is reserved for patients who can't tolerate oral form. I.V. and oral dosages are identical.

• For I.V. use, reconstitute vial with 2.7 ml of sterile water for injection; administer over 1 to 2 minutes. After reconstitution, drug is stable for 4 hours at room temperature.

• Be aware that vitamin K reverses warfarin effects. If major bleeding occurs, fresh frozen plasma may be given.

• When converting to warfarin from heparin, give both drugs concomitantly for 4 to 5 days until therapeutic effect of warfarin occurs.

Adverse reactions

GI: nausea, vomiting, diarrhea, abdominal cramps, stomatitis, anorexia

GU: hematuria

Hematologic: eosinophilia, bleeding, hemorrhage, agranulocytosis, leukopenia

Hepatic: hepatitis

Skin: rash, dermatitis, urticaria, pruritus, alopecia, dermal necrosis

Other: fever, "purple toes" syndrome (bilateral painful, purple lesions on toes and sides of feet), hypersensitivity reaction


Drug-drug. Abciximab, acetaminophen (chronic use), androgens, aspirin, capecitabine, cefamandole, cefoperazone, cefotetan, chloral hydrate, chloramphenicol, clopidogrel, disulfiram, eptifibatide, fluconazole, fluoroquinolones, itraconazole, metronidazole (including vaginal use), nonsteroidal anti-inflammatory drugs, plicamycin, quinidine, quinine, sulfonamides, thrombolytics, ticlopidine, tirofiban, valproic acid, zafirlukast: increased response to warfarin, greater risk of bleeding

Barbiturates, hormonal contraceptives containing estrogen: decreased anticoagulant effect

Drug-diagnostic tests. Alanine aminotransferase, aspartate aminotransferase, INR: increased values

Partial thromboplastin time, PT: prolonged

Drug-food. Vitamin K-rich foods (large amounts): antagonism of anticoagulant effect

Drug-herbs. Angelica: prolonged PT Anise, arnica, asafetida, bromelain, chamomile, clove, danshen, devil's claw, dong quai, fenugreek, feverfew, garlic, ginger, ginkgo, ginseng, horse chestnut, licorice, meadowsweet, motherwort, onion, papain, parsley, passionflower, quassia, red clover, Reishi mushroom, rue, sweet clover, turmeric, white willow, others: increased risk of bleeding

Coenzyme Q10, green tea, St. John's wort: decreased anticoagulant effect

Drug-behaviors. Alcohol use: enhanced warfarin activity

Patient monitoring

• Monitor PT, INR, and liver function tests.

• Watch for signs and symptoms of bleeding and hepatitis.

Patient teaching

Explain therapy to patient. Stress importance of adhering to schedule for laboratory tests.

Instruct patient to promptly report unusual bleeding or bruising.

• Caution patient to consult prescriber before taking over-the-counter preparations or herbs.

• Advise patient to inform all other health care providers (including dentist) that he is taking warfarin.

• Tell patient not to vary his intake of foods high in vitamin K (such as leafy green vegetables, fish, pork, green tea, and tomatoes), to avoid alterations in drug's anticoagulant effect.

Instruct females of childbearing age to report pregnancy immediately.

• Stress importance of avoiding contact sports and other activities that could cause injury and bleeding.

• Caution patient to avoid alcohol during therapy.

• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, tests, foods, herbs, and behaviors mentioned above.


McGraw-Hill Nurse's Drug Handbook, 7th Ed. Copyright © 2013 by The McGraw-Hill Companies, Inc. All rights reserved


A trademark for the drug warfarin sodium.


A trademark for the sodium form of the anticoagulant warfarin.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.


An anticoagulant that inhibits synthesis of liver-dependent coagulation factors (the prothrombin complex, factors II, VII, IX and X), which are formed by gamma-carboxylation of precursor proteins.
Prevention of uncomplicated distal DVT, prophylaxis and prevention of thromboembolism, post-acute myocardial infarction.

Warfarin therapy is monitored by serial evaluation of PT–2-3-fold > normal 12–16 seconds; its activity is increased by phenylbutazone, clofibrate (by outcompeting with warfarin for plasma-protein binding sites and decreased by barbiturates, which stimulate hepatic metabolism).
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.


Warfarin, see there.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.


A brand name for WARFARIN.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

Patient discussion about Coumadin

Q. Have been taking Coumadin for 10 years and wonder how this will affect my overall health...?

A. It depends on the reason for which you take it. Usually, in the majority of the patients coumadin is given in order to prevent formation of clots in the blood. If these clots get stuck in an important organ, e.g. the brain, you can guess how bad it could be (in this example it would cause a stroke, a devastating condition). Therefore, it worth to take this medication (along with the inconveniencies and risk) to the rest of your life, because it'll make sure you'll stay alive to take it....

Generally, medications, especially potent ones like coumadin are proved to improve and prolong life of the patients before they are recommended.

Q. Looking to find some folks who are taking coumadin, yet are very active to the point of having many problems. Officiating basketball with bleeding in legs.

A. my grandfather takes coumadin and is sort of active... he tries to stay in shape. he asked his doctor about that and he said that there are 2 problems that can occur. first one is injuries that can be very dangerous. and the second is extreme blood pressure changes- that can raise the chances of brain hemorrhage- this can be lethal. so he instructed him to so "soft" sports. and not to over do it.

More discussions about Coumadin
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Coumadin, also called warfarin, is a common blood thinner used to treat or prevent blood clots after surgery.
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My midwife also assured me that coumadin (warfarin), too, is safe for breastfeeding mothers and infants.
These included Coumadin, which she didn't trust in the first place due to her husband's experience.
Booth again urges caution, saying that supplemental forms of menaquinones have not been studied sufficiently, especially for how they interact with drugs like Coumadin.
FDA approves updated warfarin (coumadin) prescribing information.
They also found that ginkgo does not interfere with the action of drugs like Coumadin.
Other popular anti-aging compounds on the company's shelves include cinnamon for diabetes prevention; reishi, a revered Chinese longevity mushroom that fights high blood pressure and high cholesterol (avoid this one if taking blood thinners like Coumadin); and coffee berry, which has potent antioxidant properties.
residents use the inexpensive pills, which are sold as Coumadin, for example.