co-stimulation

(redirected from Costimulatory effect)

co-stimulation

Immunology The delivery of a 2nd signal from an antigen-presenting cell to a T cell, which rescues an activated T cell from anergy, allowing it to produce the lymphokines necessary for production of additional T cells
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
The costimulatory effect may be imparted by receptors, for example, 4-1BB [47], CD28 [48], or ICOS [49].
The synergetic costimulatory effect of CD80 is very important in activating primitive T-cells, and it is a prerequisite in the activation of adaptive immune responses [12, 13].
Activation of these receptors can induce a costimulatory effect and IL-2 secretion by T cells and IL-12 secretion by macrophages [24,25] and serves as antiapoptotic signals for macrophages under viral infection [26].
Kabelitz, "Direct costimulatory effect of TLR3 ligand poly(I:C) on human yd lymphocytes," Journal of Immunology, vol.
O'Brien et al., "Expression and costimulatory effects of the TNF receptor superfamily members CD134 (OX40) and CD137 (4-1BB), and their role in the generation of anti-tumor immune responses," European Journal of Immunology, vol.